Clinical trial · Observational
Using QPOP to Predict Treatment for Sarcomas and Melanomas
Q-SAM (Using QPOP to Predict Treatment for Sarcomas and Melanomas)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a multi-cohort proof of concept study involving patients with sarcomas or melanomas. Patient models, both two- and three-dimensional, will be derived from tumour samples. These will then be used to evaluate drug sensitivities ex vivo. Enrolled patients will undergo resections or biopsies as part of standard-of-care, which will be used to generate patient models. Patients will receive standard-of-care systemic treatment. Patient models will also be subjected up to a 14-drug screening panel. The majority of drugs in the respective drug panels has been shown to have activity in the respective cancers and would be used in the standard-of-care setting by treating physicians.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (3)
- measure
- Percentage of patients with successful model generation for each tumour subtype.
- timeFrame
- 8 years.
- description
- Patients enrolled on study will undergo resection or biopsy of fresh tumour tissue to obtain cells for the generation of models.
- measure
- Rates of radiological response from QPOP-directed treatment regimens.
- timeFrame
- 8 years.
- description
- Complete and partial clinical response and stable disease.
- measure
- Survival outcomes from QPOP-directed treatment regimens.
- timeFrame
- 8 years.
- description
- Overall survival, progression-free survival.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 21 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosis of sarcoma or melanoma * At least 1 tumour lesion amenable to fresh biopsy or resection * Signed informed consent from patient or legal representative * Able to comply with study-related procedures Exclusion Criteria: * There are no specific exclusion criteria if patients meet the inclusion criteria
References
Publications (0)
Data not yet available