Clinical trial · Interventional
Study of SHR-1701 Plus BP102 in Subjects With Selected Solid Tumors
A Multicenter, Open-Label, Phase Ib/II Trial of SHR-1701 Plus BP102 in Subjects With Selected Solid Tumors
NCT04974957CI-TRIAL-00052862unknownPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The main purpose of this study was to assess the safety,efficacy and pharmacokinetic when combining SHR-1701 and BP102 in participants with advanced or metastatic non-squamous non-small cell lung cancer. To explore the immunogenicity of SHR-1701 and the relationship between corresponding biomarkers and therapeutic effect.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Advanced or Metastatic Non-squamous Non-small Cell Lung Cancer | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| SHR-1701；BP102 | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- SHR-1701+BP102
- interventionNames
- Drug: SHR-1701；BP102
Primary outcomes (1)
- measure
- Objective response rate (ORR)
- timeFrame
- 2 years
Secondary outcomes (4)
- measure
- Progression free survival (PFS)
- timeFrame
- 2 years
- measure
- Disease control rate (DCR)
- timeFrame
- 2 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: 1. Histologically or cytologically confirmed advanced or metastatic non-squamous non-small cell lung cancer. 2. Failed with prior systemic treatments. 3. Measurable disease, as defined by RECIST v1.1 4. The Eastern Cancer Cooperative Group (ECOG) performance status of 0 or 1 5. Life expectancy ≥ 3 months 6. Adequate hematologic and end-organ function as defined in the protocol Exclusion Criteria: 1. Histologically or cytologically confirmed mixed SCLC and NSCLC. 2. Symptomatic, untreated or active central nervous system metastases. 3. Systemic therapy with immunosuppressive agents within 2 weeks prior to initiation of study treatment 4. With any active autoimmune disease or history of autoimmune disease. 5. Inadequately controlled hypertension. 6. Tumor infiltration into the great vessels on imaging. 7. History of hemoptysis ≥2.5ml per episode within 1 month prior to initiation of study treatment. 8. Uncontrolled tumor-related pain. 9. Patients with active hepatitis B or hepatitis C 10. Severe infections within 4 weeks prior to initiation of study treatment. 11. Active tuberculosis within one year prior to initiation of study treatment.
References
Publications (0)
Data not yet available
No reference posted for this study.