Oral Health Condition and Quality of Life in Children With Leukemia

Among the different types of cancer that most affect children, leukemia is the principal. One of the main treatments for leukemia is chemotherapy. Among the most common side effects of chemotherapy are nausea and/or vomiting, diarrhea, fatigue, alopecia, neuropathy, opportunistic infections, and oral mucositis. It is still necessary to establish which microorganisms are predominant in the oral microbiota of children with leukemia, which factors influence it, what is its relationship with oral mucositis and what is their impact in the quality of life. To better understand the risks of secondary infection, it is important to develop preventive and/or therapeutic strategies to control the side effects of antineoplastic treatment in the mouth that may negatively impact the quality of life, to expose the risk of death as well as raise hospital costs for the care of children with leukemia. Objective: To identify the clinical characteristics of the oral condition, types of microorganisms of the oral microbiota, and quality of life in children/adolescents with acute lymphoid leukemia and acute myeloid leukemia before and during antineoplastic treatment, and compare them with healthy children/adolescent individuals. Methodology: Longitudinal, case-control study, with a convenience sample. The study group, composed of children/adolescent individuals who have a definitive diagnosis of acute lymphoid leukemia or acute myeloid leukemia. The control group, non-syndromic children/adolescents, with no history of cancer, matched by age and gender. The clinical condition of the mouth will be evaluated by means of indexes: dental caries index (dmft index), gingival index (GA), and simplified oral hygiene index. The assessment of the quality of life through the ohip-14 and POS-version14 quality of life questionnaire and microbiological evaluation of saliva through MALDI-TOF analysis. Statistical analysis will be performed through relative risk for cohort study with more than three paired groups. Odds ratio, for the control group more than three controlled groups and Mcnemere, for comparison with the control group, for more than three paired groups.

Sex

All

Minimum age

3 Years

Maximum age

17 Years

Inclusion Criteria:

* Patients who, based on the agreement of parents and/or guardians, agree to participate in the research with a signed "Informed Consent Form"
* Patients from 3 to 17 years of age
* Patients older than 6 years must not only have parental and/or guardian authorization must have the consent term
* Patients who have not started antineoplastic treatment
* Patients with ALL only with BFM protocol
* AML patients with BFM protocol only

Exclusion Criteria:

* Responsible for patients who do not sign the free and informed consent form.
* Patients under three years of age and over 17 years of age
* Children older than six years who do not agree to the term of assent
* Patients who have started antineoplastic treatment
* Patients with syndromes and/or other systemic diseases associated with the diagnosis of lymphoid and acute myeloid leukemia
* Neoplasms other than lymphoid leukemia or acute myeloid

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