Clinical trial · Observational
Effect and Prognosis of Immunohistochemical Biomarkers Changes in Patients With Bladder Cancer After Neoadjuvant Chemotherapy
NCT04966975CI-TRIAL-00052748unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Clinical trial to investigate the relationship between the expression of immunohistochemical biomarkers GATA-3, CK20, P53 and Ki67 in bladder cancer and pathological complete response after neoadjuvant chemotherapy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bladder Cancer | Malignant Bladder Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| neoadjuvant chemotherapy | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Histologically confirmed bladder cancer treated with NAC
- interventionNames
- Other: neoadjuvant chemotherapy
Primary outcomes (2)
- measure
- Expression of immunohistochemical biomarkers GATA-3, CK20, P53 and Ki67
- timeFrame
- 1 year
- measure
- Tumor regression grade
- timeFrame
- 1 year
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: 1. Any male or female patient aged 18 or older. 2. Histologically confirmed bladder cancer, cystectomy was performed after NAC. 3. Complete clinical data. Exclusion Criteria: 1. Patients with severe organic disease who can not tolerate chemotherapy or surgery 2. Patients received previous treatment (chemotherapy, radiation, or molecular targeted therapy). 3. Patients with distant metastasis or other cancer history.
References
Publications (0)
Data not yet available
No reference posted for this study.