Clinical trial · Interventional
Gender/Sex & CUD Remission
Gender and Sex Hormone Influences on Cannabis Use Disorder Remission
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Adults (ages 18+) who would like to reduce their cannabis use (N=224) will be enrolled in an 8-week treatment program. All participants will receive counseling (1 goals session with a therapist followed by 7 weekly computerized cognitive-behavioral therapy sessions). Detailed cannabis assessments (biological and self-report) will be conducted throughout treatment and at 1-, 2-, and 3-months post-treatment completion. Daily electronic diaries will be administered via text message to record detailed logs of cannabis use quantity and frequency. Salivary samples will be collected (and video observed) daily throughout treatment to analyze for progesterone.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cannabis Use Disorder, Mild | — | UNRESOLVED | — |
| Cannabis Use Disorder, Moderate | — | UNRESOLVED | — |
| Cannabis Use Disorder, Severe | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cognitive Behavioral Therapy (CBT4CBT) | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- OTHER
- label
- Cognitive Behavioral Therapy - Men
- description
- 112 participants identifying as men will be enrolled in 8 weeks of behavioral treatment for cannabis use disorder (CUD). They will receive a motivational interviewing session with a therapist followed by 7 weekly online modules of CBT4CBT with continued monitoring and support from a therapist. Gender and hormonal factors will be examined as predictors of CUD remission and cannabis outcomes.
- interventionNames
- Behavioral: Cognitive Behavioral Therapy (CBT4CBT)
- type
- OTHER
- label
- Cognitive Behavioral Therapy - Women
- description
- 112 participants identifying as women will be enrolled in 8 weeks of behavioral treatment for CUD. They will receive a motivational interviewing session with a therapist followed by 7 weekly online modules of CBT4CBT with continued monitoring and support from a therapist. Gender and hormonal factors will be examined as predictors of CUD remission and cannabis outcomes.
- interventionNames
- Behavioral: Cognitive Behavioral Therapy (CBT4CBT)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Willingness to participate in a research study (otherwise, will be referred to appropriate clinical services if seeking clinical care). 2. Meet current (within last 30 days) DSM-5 criteria for cannabis use disorder. 3. Submit a positive urine cannabinoid test during screening. 4. Interested in treatment for cannabis use disorder. Exclusion Criteria: 1. Significant or acutely unstable medical or psychiatric problems (i.e., psychosis, mania) that would contraindicate research procedures, interfere with safety, compromise data integrity, or preclude consistent study participation. 2. The presence of any substance use disorder requiring a higher level of care. 3. Significant risk of homicide or suicide. 4. Pregnant, trying to become pregnant, or breastfeeding.
References
Publications (0)
Data not yet available