'Lung Health Check' Biomarker Study

CT screening of lung cancer offers an opportunity to diagnose early stage lung cancers which is associated with better prognosis - indeterminate results delay diagnosis whilst interval imaging is awaited to assess risk of cancer. This study will allow us to examine the potential of blood-based biomarkers to augment CT screening for lung cancer. Hypotheses 1. Blood and sputum samples can be collected in patients attending lung health checks as part of the Lung Health Check pilot in West London at fixed and mobile scanners and safely transported for processing and storage in preparation for biomarker development. 2. The biomarkers will help to identify cohorts of 1. High-risk patients in whom CT surveillance should be conducted more readily/frequently and diagnostic procedures performed earlier. 2. Low-risk patients who might need reduced surveillance intensity. 3. Patients with interstitial lung abnormalities that share similar biomarker characteristics to patients with clinically significant interstitial lung disease

Sex

All

Minimum age

55 Years

Maximum age

75 Years

Inclusion Criteria:

* Patients invited to participate in the Royal Marsden (RM) Partners Lung Health Check pilot study who undergo one or more CT scans:
* Between the age of 55-75 years of age; and
* Current smokers or ex-smokers who have quit after the age of 40.

Exclusion Criteria:

* Patients excluded from the Lung Health Check:
* On the palliative care register;
* Any active malignancy undergoing treatment
* Daily activity levels equivalent to performance score 3 or 4; and
* Unable to consent to Lung Health Check Biomarker Study

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