Clinical trial · Interventional
A Trial of SHR1701 Plus Chemotherapy in Patients With Gastric or Gastroesophageal Cancer
A Randomized, Double-Blind, Multi-Center, Phase III Clinical Study of SHR-1701 Plus Chemotherapy Versus Placebo Plus Chemotherapy as Treatment in Patients With Previously Untreated, Advanced or Metastatic Gastric or Gastroesophageal Junction Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study is a randomized, Double-Blind, multi-center Phase III clinical study, aimed to evaluate the efficacy and safety of SHR1701 combined with chemotherapy in the treatment of Previously Untreated, Advanced or Metastatic Gastric or Gastroesophageal Junction Cancer. For Part 1 study，the tolerability of SHR-1701 will be evaluated and determine the recommended dose for Part 2.For Part 2 study, all enrolled patients will be randomized to 2 groups and continuously treated until the end criteria of treatment was met.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastric or Gastroesophageal Junction Cancer | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Placebo、CAPOX | Drug | — | UNRESOLVED |
| SHR-1701、CAPOX | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Treatment group A
- interventionNames
- Drug: SHR-1701、CAPOX
- type
- PLACEBO_COMPARATOR
- label
- Treatment group B
- interventionNames
- Drug: Placebo、CAPOX
Primary outcomes (3)
- measure
- AEs and SAEs in part 1 study
- timeFrame
- up to 2 years
- description
- The number and proportion of subjects with dose limiting toxicity. The safety endpoints, including incidence and severity of adverse events (AEs) and serious adverse events (SAEs).
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Pathologically confirmed diagnosis of locally advanced unresectable or metastatic gastric or gastroesophageal junction (GEJ)adenocarcinoma. 2. HER2 overexpression or amplification negative. 3. Female or male, 18 years of age or above. 4. Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 1. 5. Patients who are willing and able to provide the signed informed consent form, willing and able to comply with all the scheduled visits, study treatment, laboratory tests, and other study procedures. Exclusion Criteria: 1. Squamous cell carcinoma, undifferentiated carcinoma, or other histological types of gastric cancer. 2. Presence of inadequately treated CNS metastases, or uncontrolled or symptomatic active CNS metastases ，leptomeningeal disease, and/or rapid progression. 3. Presence of uncontrolled pleural effusion or ascites despite puncture drainage within 14 days prior to randomization. 4. More than 20% weight loss within 2 months prior to randomization. 5. Diagnosed with other malignant tumors within 5 years prior to enrollment. 6. Presence of any active, known or suspected autoimmune disease. 7. Prior treatment with TGF-β inhibitor, anti-PD-1/PD-L1 antibodies, anti-PD-L2 antibodies, anti-CD137 antibodies, anti-CTLA-4 antibodies, or other drugs/antibodies. 8. Severe, unhealed, or dehisced wounds and active ulcers or untreated fractures.
References
Publications (0)
Data not yet available