Clinical trial · Observational
Breath Combined With CT for Diagnoses of Pulmonary Nodules
Assessment of the Efficacy of Breath Test Combined With Computed Tomography for Diagnoses of Pulmonary Nodules.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Pulmonary nodules diagnosis using breath test of volatile organic compound (VOC) is in its infancy. The accuracy of VOC analysis in diagnosing malignant pulmonary nodules varies cross the published studies. The diagnosis accuracy of VOC alone is generally poor. We speculate that the accuracy of diagnosing malignant pulmonary nodules will be improved by combining breath test with chest computed tomography (CT). This study aims to establish a predictive model of malignant pulmonary nodule using bio-markers from exhaled breath and image-markers from chest CT with retrospective data from multi centers. The sensitivity, specificity and accuracy of the model will be validated prospectively.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Non-small Cell Lung Cancer | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
| Pulmonary Nodule, Multiple | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Breath test combined with computed tomography | Diagnostic Test | — | UNRESOLVED |
| Pathological examinations as the golden diagnosis criteria | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Malignant pulmonary nodules
- description
- Patients with pulmonary nodule diagnosed as malignant cancer by pathological examinations after surgical resection.
- interventionNames
- Diagnostic Test: Pathological examinations as the golden diagnosis criteria
- Diagnostic Test: Breath test combined with computed tomography
- label
- Benign pulmonary nodules
- description
- Patients with pulmonary nodule diagnosed as benign disease by pathological examinations after surgical resection.
- interventionNames
- Diagnostic Test: Pathological examinations as the golden diagnosis criteria
- Diagnostic Test: Breath test combined with computed tomography
Primary outcomes (3)
- measure
- Diagnostic sensitivity of breath test combined with computed tomography
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age \> 18 years old; 2. Pulmonary nodules with planned surgical resection; 3. Signed informed consent and agreed to participate in this study. Exclusion Criteria: 1. Preoperative radiotherapy, chemotherapy, targeted therapy or other anti-tumor therapy 2. The lack of chest computed tomography within two weeks before surgery 3. A history of malignant disease within 5 years.
References
Publications (0)
Data not yet available