Clinical trial · Interventional
Physical Activity Post-Cancer for Adolescents and Young Adults
Physical Activity Post-Cancer for Adolescents and Young Adults (PAPAYA)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The Physical Activity Post-Cancer for Adolescents and Young Adults (PAPAYA) trial aims to carry out a pilot randomized controlled trial among 10-17 year-old adolescents and young adults, at least 1 year and up to 5 years post-cancer treatment. The trial will evaluate the effects of a 12 week physical activity intervention to improve patient reported outcomes and physical function, in comparison to a delayed-intervention control group.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Childhood Cancer Survivors | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Physical Activity | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Physical activity intervention group
- description
- The physical activity intervention will be structured to increase moderate-to-vigorous intensity aerobic physical activity, to achieve the 60-minute goal, five days per week. The intervention will also include weekly support calls from research staff to improve compliance to physical activity intervention.
- interventionNames
- Behavioral: Physical Activity
- type
- OTHER
- label
- Delayed-intervention control group
- description
- Participants randomized to the delayed-intervention control group will serve as the control group for 12 weeks, and will not receive physical activity intervention during this time and will not receive weekly support calls. After completion of the control group, participants will be offered physical activity advice according to the Children's Oncology Group Guidelines for Diet and Physical Activity recommendations. This delayed-intervention control group design is used not only to boost recruitment, but to eventually confer the benefits of physical activity to all those who enter the trial.
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 10 Years
- Maximum age
- 17 Years
Show eligibility criteria text
Inclusion Criteria: Adolescent and young adult inclusion criteria will be as follows: 1. males and females diagnosed with cancer; 2. treated at Penn State Health Children's Hospital or Penn State Cancer Institute, Milton S. Hershey Medical Center; 3. at least 1 year and up to 5 years post-cancer treatment; 4. being aged between 10 to 17 years old at enrollment; 5. being able to speak, read and understand the English language; 6. adolescents and young adults have to be able to assent, and parents/guardians have to be able to consent to the study in an informed manner; 7. Parent fluency in written and spoken English; 8. Adolescents and young adults or their parents must have access to a phone or Zoom Note: The agreement of the attending oncologist will be required for the participation of adolescents and young adults eligible for this study. Exclusion Criteria: Adolescent and young adult exclusion criteria will be as follows: 1. Received follow-up at a location other than Penn State Health Children's Hospital or Penn State Cancer Institute, Milton S. Hershey Medical Center; 2. Evidence in the medical record of an absolute contraindication for physical activity; 3. cardiac exclusion criteria: Class II, III or IV heart failure as defined by the New York Heart Association (NYHA) functional classification system, history of acute coronary syndromes, uncertain or uncontrolled arrhythmia, uncontrolled hypertension, syncope, acute myocarditis, pericarditis, or endocarditis, acute pulmonary embolus or pulmonary infarction, thrombosis of lower extremities, suspected dissecting aneurysm, pulmonary edema, respiratory failure, acute non-cardiopulmonary disorder that may affect exercise performance or be aggravated by exercise, mental impairment leading to inability to cooperate; 4. History of refractory or recurrent diseases 5. Already meeting physical activity guidelines.
References
Publications (1)
- DERIVEDCaru M, Dandekar S, Gordon B, Conroy DE, Barb ED, Doerksen SE, Smink GM, McKeone DJ, Shah NB, Greiner RJ, Schramm JW, Rao P, McGregor L, Schmitz KH. Implementing a behavioral physical activity program in children and adolescent survivors of childhood cancer: a pilot randomized controlled trial. J Behav Med. 2024 Oct;47(5):792-803. doi: 10.1007/s10865-024-00497-z. Epub 2024 May 12. PMID 38735024