Adjuvant Therapy With Anlotinib for HCC

Inclusion Criteria:

* Aged from 18-75 years.
* HCC diagnosis was confirmed by pathological examination and those who did not receive anti-tumor treatment (anti-tumor treatment including but not limited to: local ablation therapy, TACE, radiation therapy, chemotherapy, targeted drug therapy, immunotherapy, and etc.)
* Underwent curative resection for HCC with high risk of tumor recurrence, which was defined by Shanghai Score ≥ 4.922 (Sun, et al. Chin Med J (Engl) 2017)
* Child-Pugh class: A or B7
* The ECOG Performance Status: 0-1 points
* The expected survival time ≥ 6 months
* No disease recurrence 4-6 weeks after surgery as evaluated by abdominal contrast-enhanced CT/MRI and chest CT.
* Adequate organs function
* Complete blood counting HB ≥ 90 g/L ANC ≥ 1.5×10\^9 /L PLT ≥ 75×10\^9/L
* Blood biochemistry ALB ≥ 28 g/L ALT and AST\< 5×ULN TBIL ≤ 2×ULN Serum creatinine ≤ 1×ULN
* Women of childbearing age must have pregnancy tests within 7 days prior to admission, and the results are negative and are willing to use appropriate methods of contraception at 8 weeks after the trial and at the end of the trial. For men, surgical sterilization should be applied, or consent to use appropriate methods of contraception 8 weeks after the trial and at the end of the trial.
* Subjects voluntarily participated in the study, signed informed consent, good compliance in drug therapy and followed up.

Exclusion Criteria:

* Cholangiocarcinoma, the combination of cholangiocarcinoma of HCC, or fibrolamellar HCC diagnosed by pathology examination.
* Past or current diagnosed with other malignancy, except skin basal cell carcinoma and cervical carcinoma in situ.
* Those treated with liver or other organ transplantation or willing to undergo liver transplantation.
* The conditions not suitable for oral medications, including difficulty swallowing, chronic diarrhoea, or bowel obstruction.
* Vascular events within 6 months, including stroke and transient ischemic attack

  , deep venous thrombosis or pulmonary artery embolism.
* Alimentary tract hemorrhage or high risk of alimentary tract hemorrhage due to esophageal varices, active ulcerative lesions or ulcerative colitis; or fecal occult blood test ≥ ++, or for those with fecal occult blood test (+), gastroscopy is required.
* Abnormal coagulation function (international normalized ratio \> 2, prothrombin time \> 16 s, thrombin time \>21s, activated partial thromboplastin time \> 21 s, or fibrinogen \< 2 g/L); or other conditions with bleeding tendency or undergoing thrombolysis or anticoagulant therapy.
* Other severe or uncontrolled comorbidities:
* hypertension and the blood pressure was not well managed by medications (systolic pressure ≥ 150 mmHg or diastolic pressure ≥ 90 mmHg); level 2 or higher myocardial ischemia or myocardial infarction, uncontrolled arrhythmia (including QTc interval ≥ 480 ms); level 1 heart dysfunction; or LVEF \< 50%.
* active or uncontrolled infection.
* uncontrolled diabetes (fasting blood glucose \> 10 mmol/L).
* Urinary protein ≥ ++ or 24 hours urine protein \> 1 g.
* Unhealed wounds, ulcer, or bone fracture.
* Those with mental illness or a history of psychotropic substance abuse; HIV infection.
* Other conditions that the investigators considered that not suitable for trial inclusion.