Clinical trial · Interventional
Efficacy of Epidural Analgesia in Lower Extremity Osteosarcoma
Efficacy of Epidural Analgesia Initiated in the Preoperative Period in Lower Extremity Osteosarcoma
NCT04945512CI-TRIAL-00054947unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In this study, the investigators aim to reduce complications in orthopedic malignancy surgeries and to increase the quality of life of patients who will be operated on.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Analgesia | — | UNRESOLVED | — |
| Osteosarcoma | Osteosarcoma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Epidural Analgesia | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Study group; Epidural catheter and PCA
- description
- Epidural catheter will be placed in the preoperative period. After induction, 10 ml of 0.25% bupivacaine will be administered through the epidural catheter and bupivacaine PCA will be started.
- interventionNames
- Procedure: Epidural Analgesia
- type
- NO_INTERVENTION
- label
- Control group; No block, IC PCA
- description
- Postoperative pain control will be achieved with intravenous morphine PCA.
Primary outcomes (2)
- measure
- Opioid consumption
- timeFrame
- 48 hours
- description
- miligram
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * accepting the study protocol, * age older than 18 years and younger than 80 years, * undergoing lower extremity osteosarcoma surgery * the American Society of Anesthesiologist (ASA) physical status of I-II-III Exclusion Criteria: * infection at the injection site * coagulation disorder * patients with central nervous system related disease * septic patients
References
Publications (2)
- RESULTRawal N. Current issues in postoperative pain management. Eur J Anaesthesiol. 2016 Mar;33(3):160-71. doi: 10.1097/EJA.0000000000000366. PMID 26509324
- RESULTWeinbroum AA. Superiority of postoperative epidural over intravenous patient-controlled analgesia in orthopedic oncologic patients. Surgery. 2005 Nov;138(5):869-76. doi: 10.1016/j.surg.2005.05.004. PMID 16291387