Clinical trial · Interventional
The Application of Glucose CEST MR Imaging in Brain Tumor
The Evaluation of D-glucose Weighted Chemical Exchange Saturation Transfer (gluceoCEST)-Based Dynamic Glucose Enhanced(DGE) Magnetic Resonance Imaging（MRI） in Brain Tumor
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Recently, natural D-glucose was suggested as a potential biodegradable contrast agent. The feasibility of using D-glucose for dynamic perfusion imaging was explored to detect malignant brain tumors based on blood brain barrier breakdown. Our study try to evaluate the feasibility of dynamic glucose enhanced(DGE) magnetic resonance imaging（MRI）in brain tumor, which based on D-glucose weighted chemical exchange saturation transfer (gluceoCEST).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Magnetic Resonance Imaging | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| d-glucose | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- D-glucose
- description
- During the dynamic glucose scan, a brief hyperglycemic state was established by intravenous infusion of hospital-grade D50 glucose (D50, 25 g of dextrose in 50 mL of water sterile solution), followed by 20 mL of saline solution in 1 arm. The glucose infusion was performed using a power injector at an infusion rate of 0.2 mL/s, corresponding to total infusion times 250 seconds.
- interventionNames
- Drug: d-glucose
Primary outcomes (1)
- measure
- CEST value of tumor lesion including tumor core/ necrosis/ cysis/ edema
- timeFrame
- 1 week
- description
- the CEST value of tumor core and necrosis might higher than white matter
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Patient must have a brain mass consistent with a primary brain tumor or metastatic brain tumor * able to give consent and willingness to participate in this study. Exclusion Criteria: * presence of any ferromagnetic implant (cardiac pacemakers, aneurysm clip, etc.) * pregnancy * claustrophobia or anxiety disorder * history of vertigo * persons with diabetes mellitus (self-report or HbA1C \>= 6.5%) * Sickle cell disease * persons taking prescription medicine for hypertension * blood iron deficiency (Hb concentration \< 11 g/dL or Hct \< 32%) * If volunteering for MRI: history of kidney disease and/or eGFR \< 60. * Middle-ear disorder * double vision * Seizure disorder * Multiple myeloma * Solid organ transplant * History of severe hepatic disease/liver transplant/pending liver transplant
References
Publications (0)
Data not yet available