Clinical trial · Interventional
STRATEGIES to Improve Memory in Alzheimer's Disease
Improving Memory in Daily Life of Patients With Alzheimer's Disease
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Study was never started due to the Covid 19 pandemic.
Summary
Brief summary (as posted)
Memory mistakes are one of the most detrimental symptoms in Alzheimer's Disease (AD). In this study the investigators will measure the long-term efficacy of memory strategies in patients with AD. First, the efficacy of the strategies will be evaluated in the laboratory by analyzing the behavioral response and the brain activity of the patients. During the first visit, patients will be taught the memory strategies and asked to repeat them at home for 4 weeks. During this period of time, patients will perform several memory tasks while their performance and brain activity will be measured using portable devices. Monitoring brain activity and behavioral responses to memory tasks will provide insightful information on the efficacy of the strategies and allow the investigation of how patients can maintain the strategies over time. The research will examine if improving memory through the use of cognitive strategies, can positively affect other domains of daily life.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Alzheimer Disease | — | UNRESOLVED | — |
| Dementia, Mild | — | UNRESOLVED | — |
| Mild Cognitive Impairment | — | UNRESOLVED | — |
Interventions
Interventions (6)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Electroencephalogram (EEG) headset in Arm 1 | Device | — | UNRESOLVED |
| Electroencephalogram (EEG) headset in Arm 2 | Device | — | UNRESOLVED |
| Memory strategies in Arm 1 | Behavioral | — | UNRESOLVED |
| Memory strategies in Arm 2 | Behavioral | — | UNRESOLVED |
| Tablet in Arm 1 | Other | — | UNRESOLVED |
| Tablet in Arm 2 | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Group 1- 15 Mild AD and 15 MCI due to AD
- description
- In Group 1, for the first 2 weeks participants will be taught memory strategies and reminded to use them each day from week 0 to week 2. Weeks 3-4, participants will be advised to keep using the strategies both on the tablet and in their daily life even though they will not be reminded each time they start the task.
- interventionNames
- Behavioral: Memory strategies in Arm 1
- Device: Electroencephalogram (EEG) headset in Arm 1
- Other: Tablet in Arm 1
- type
- ACTIVE_COMPARATOR
- label
- Group 2- 15 Mild AD and 15 MCI due to AD
- description
- In Group 2, for the first 2 weeks participants will be reminded to "try hard" to remember the items although they will not be given any specific strategies. At week 2 the subjects will be taught memory strategies and reminded to use them each day from week 2 to week 4.
- interventionNames
- Behavioral: Memory strategies in Arm 2
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: For Mild Alzheimer Disease (AD) dementia * meets probable AD dementia National Institute on Aging and Alzheimer's Association (NIA-AA) criteria * Mini-Mental State Examination (MMSE) 20-27 * performance on delayed recall and recognition memory worse than 1.5 standard deviation (SD) for age and education * performance on delayed recall and recognition memory worse than 1.5 SD for age \& education in at least one other cognitive domain (e.g., language, executive functioning) based on other tests in our neuropsychological test battery. * Dr. Turk and Dr. Budson will confirm all mild AD dementia diagnoses For Mild cognitive impairment (MCI) * meets MCI due to AD NIA-AA criteria * MMSE \> 23 * performance on delayed recall and recognition memory worse than 1.0 SD for age \& education adjusted norms * Dr. Turk and Dr. Budson will confirm all MCI due to AD diagnoses Exclusion Criteria: A clinically significant problem of any of the following conditions: * depression * heavy alcohol or drug use * cerebrovascular disease * traumatic brain damage * a different degenerative disease (e.g., fronto-temporal dementia, Parkinson's disease) * any medical condition whose severity could significantly impair cognition (e.g., organ failure) * Unable to understand the consent form
References
Publications (0)
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