A Study in Patients With Advanced Breast Cancer

Inclusion Criteria:

1. All 3 parts of Study:

   * Male or females, Age 18 years or older
   * Histologically or cytologically diagnosed with ER+/HER2- adenocarcinoma of the breast cancer with an evidence of metastatic/loco-regionally recurrent disease/unresectable advanced disease not amenable to treatment with curative intent
   * Documentation of ER-positive, HER2-negative status determined based on a biopsy performed at or after diagnosis of local or metastatic recurrence, utilizing an assay consistent with local standards
   * Not more than 3 prior chemotherapeutic regimens
   * ECOG performance status 0-1.
   * Resolution of all adverse events of prior therapy or surgical procedures to National Cancer Institute (NCI) CTCAE v 5.0 Grade ≤1 (except alopecia)
   * Adequate organ and immune system function as indicated by laboratory values
   * Patients of childbearing potential must practice an acceptable method of birth control as judged by the Investigator
   * Female subjects must be non-lactating and non-breast feeding
   * Male subjects should not father a child and must practice an acceptable method of birth control measures Willing and available to participate for the entire study
   * Willing and able to comply with protocol requirements
2. For Part 1\& 2:

   * Patient must have evaluable disease (according to RECIST 1.1).
   * Documented disease progression or resistance to at least 1 prior endocrine therapy (with or without CDK 4/6 therapy).
3. For Part 3

   * Patient must have measurable lesions (according to RECIST 1.1)
   * Part 3a: HR+ve, HER2- MBC patients with ESR1 mutations, resistance to atleast one priro endocrine therapy
   * Part 3b: HR+ve HER2- MBC patients resistant to atleast one priro endocrine therapy
   * Part 3c: HR+ve HER2- MBC patients resistant to atleast one priro endocrine therapy, disease progression on Fulvestrant and CDK4/6i
   * Part 3d: Brain metastases secondary to ER+ve HER-ve Breast Cancer:

Measurable brain lesion (≥ 1) as per RANO-BM Criteria, Tretament naive/ Treated- Stable/ Not requiring immediate local therapy known/ Suspected leptomeningeal disease on Stable corticosteriod dose for 7 days prior screeing

Exclusion Criteria:

1. All 3 parts of Study

   * Major surgery \<4 weeks of C1D1
   * Evidence of organ dysfunction or inadequate bone marrow reserve or any clinically significant finidngs
   * Patients with visceral crisis or impending visceral crisis and rapidly progressing disease
   * Serology tests +ve for HIV, HCV, HBsAg
   * Inability to swallow oral medication
   * H/o any relevant allergy/hypersensitivity/idiosyncrasy to drugs/ chemically related to Study drug or its excipients
   * Received an IMP within 30 days/5 half life to C1D1
   * Prior treatment with other oral SERDs
   * Use of concomitant medication that might reasonably influence the results or interpretation of the study
   * Requires concurrent systemic anticancer treatment at any time during the study treatment period
   * Known or suspected history of significant drug abuse/Alcohol as judged by the Investigator
   * Known or suspected history of excessive intake of alcohol in the 12 months prior to study entry
   * Malabsorption syndrome/IBD/other illness that would affect oral absorption of Study drug
   * Uncontrolled intercurrent illness that would limit compliance with study requirements / have impact on endpoints / safety
   * ≤6 months H/o MI/unstable angina, ongoing \> G2 cardiac dysrhythmia, prolonged QTcF/ uncontrolled AF, coronary/peripheral artery bypass graft, HF of NYHA\_Class II or greater and CVA (+TIA)
   * H/o Endometrial intraepithelial neoplasia, other malignancy \< 5 yrs prior to enrollment
   * Known active uncontrolled or symptomatic Central Nervous System (CNS) metastases, or leptomeningeal disease as indicated by clinical symptoms (not applicable to Part 3d), carcinomatous meningitis, cerebral edema, and/or progressive growth or pulmonary lymphangitic metastases.
   * Current abnormal vaginal bleeding or symptomatic endometrial disorders.
2. For Part 2: Use of other ET that block the estrogen receptor: atleast 8 weeks before enrollment (28 weeks for fulvestrant) For Part 2: Liver-only metastases (are not evaluable by FES-PET/CT imaging)
3. For Part 3: Any brain lesion requiring immediate local therapy (which includes but is not limited to WBRT, SRS, or surgical resection, for treatment of brain metastases) Requires increase in the dose of corticosteroids for control of CNS symptoms due to brain metastases Poorly controlled (\> 2 per month ) generalized or complex partial seizures Who are taking concurrent enzyme-inducing antiepileptic drugs (EIAED) Who has evidence of significant (ie, symptomatic) intracranial haemorrhage Contra indications for repeated MRI assessments