Clinical trial · Interventional
Effects of Hericium Erinaceus on Microbiota and Cognition
Effects of Hericium Erinaceus on Microbiota and Cognition in Older Adults
NCT04939961CI-TRIAL-00064355HEcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The study evaluates the effects of Hericium erinaceus on microbiota, cognition, and other health parameters in older adults. All measurements will be performed at baseline and ten weeks after daily consumptions of either Hericium erinaceus or placebo.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cognitive Decline, Mild | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Hericium erinaceus | Dietary Supplement | — | UNRESOLVED |
| Placebo | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Hericium erinaceus
- description
- 8 gram of mushroom Hericium erinaceus (containing 5 milligram of erinacines) per day
- interventionNames
- Dietary Supplement: Hericium erinaceus
- type
- PLACEBO_COMPARATOR
- label
- Placebo capsule
- description
- 8 gram of allergen free corn starch per day
- interventionNames
- Dietary Supplement: Placebo
Primary outcomes (1)
- measure
- Assessment of the microbial community composition in feces samples using next-generation sequencing
- timeFrame
- Change from Baseline Microbiota composition at 10 weeks.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 55 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * age 55 - 75 years Exclusion Criteria: * neurodegenerative disease * organ transplantation * allergy to fungi * antibiotic consumption in the previous 3 months
References
Publications (2)
- BACKGROUNDFriedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. J Agric Food Chem. 2015 Aug 19;63(32):7108-23. doi: 10.1021/acs.jafc.5b02914. Epub 2015 Aug 5. PMID 26244378
- BACKGROUNDChong PS, Fung ML, Wong KH, Lim LW. Therapeutic Potential of Hericium erinaceus for Depressive Disorder. Int J Mol Sci. 2019 Dec 25;21(1):163. doi: 10.3390/ijms21010163. PMID 31881712