Clinical trial · Observational
Cardiorespiratory Diagnostic Study
A Longitudinal Observational Study to Investigate the Patterns of Change in the Tidal Breathing CO2 Waveform, Measured Using the N-Tidal C Handset, in Patients With COPD Compared to Patients With Other Common Cardiorespiratory Conditions
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study uses a new breathing device called 'N-Tidal C' handset which measures breathing patterns. Investigators have found that people with cardiac and respiratory illnesses breathe out a gas, called carbon dioxide (CO2), in a different way to healthy people. The pattern of breathed out CO2 (the waveform) varies according to the underlying health of the user's lungs. Monitoring these changes may help doctors to more accurately diagnose and monitor the most common and serious respiratory conditions.
Conditions
Conditions (10)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anemia | — | UNRESOLVED | — |
| Asthma | — | UNRESOLVED | — |
| Bronchiectasis | — | UNRESOLVED | — |
| Congestive Cardiac Failure | — | UNRESOLVED | — |
| COPD | — | UNRESOLVED | — |
| Healthy | — | UNRESOLVED | — |
| Interstitial Lung Disease | — | UNRESOLVED | — |
| Long COVID | — | UNRESOLVED | — |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Upper Respiratory Disease |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| N-Tidal C handset | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (10)
- label
- Chronic Obstructive Pulmonary Disease
- description
- 245 participants - GOLD 1, 2, 3 / A, B, C
- interventionNames
- Device: N-Tidal C handset
- label
- Asthma
- description
- 55 participants - Mild to moderate, not labelled as severe.
- interventionNames
- Device: N-Tidal C handset
- label
- Congestive cardiac failure
- description
- 55 participants
- interventionNames
- Device: N-Tidal C handset
- label
- Anaemia
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age \> 18 years * Healthy volunteer (with no previous or current chronic cardiorespiratory diagnoses) One of the following cardiorespiratory diagnoses: * COPD (GOLD 1, 2, 3 / A, B, C)\* * Asthma (mild to moderate, not labelled as severe)\* * Congestive cardiac failure\* * Anaemia (with at least 50% of participants recruited having no history of chronic cardiorespiratory conditions)\* * Bronchiectasis (acquired or genetic, e.g. cystic fibrosis or other primary ciliary dyskinesias)\* * Lung cancer (including rare types e.g. mesothelioma)\* * Interstitial Lung Disease (including pulmonary fibrosis pneumoconiosis, asbestosis, sarcoidosis, amyloidosis)\* * Long COVID\* * Upper airway obstruction disorder\* * \[Active pulmonary hypertension\] * \[Extrinsic Allergic Alveolitis\] * \[Active pulmonary embolism\] Exclusion Criteria: * Participants who, in the opinion of the chief investigator, or their delegate, are unlikely to comply with the requirements of the study; * Diagnosis of neuromuscular disorders; * Concurrent diagnosis of cardiorespiratory conditions (other than those listed in the inclusion criteria above) that, in the opinion of the chief investigator, would impact the conduct of the study * Participants who are acutely unwell, e.g. active exacerbation, very short of breath e.g. severe COPD (GOLD 4 / D) or end-stage IPF. * Inability to give written informed consent
References
Publications (1)
- DERIVEDLim RH, Talker L, Broomfield H, Dogan C, Selim AB, Lambert G, Carter JC, Neville DM, Wiffen L, Brown T; BRS Team; Vijaykumar E, Chauhan AJ, Patel AX. Quantification of smoking-related airway remodelling in COPD, using N-Tidal. Sci Rep. 2026 Feb 26;16(1):8713. doi: 10.1038/s41598-026-41699-6. PMID 41748706