Clinical trial · Interventional
Connecting Families to Overcome Ovarian Cancer
Testing a Low Cost Population- and Theory-Based Outreach Intervention to Engage Ovarian Cancer Survivors and Their Close Relatives to Consider Genetic Services
NCT04927013CI-TRIAL-00081271completedN/AResults postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study tests a multi-component, low cost, message-based communication outreach intervention to engage ovarian cancer survivors and their at-risk relatives in considering cancer genetic services. The intervention includes foot-in-the-door techniques, tailored/targeted print, website support, and short messages to expand reach of prevention messages.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Ovarian Cancer | Malignant Ovarian Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Message-based Outreach Intervention for Close Relatives | Behavioral | — | UNRESOLVED |
| Message-based Outreach Intervention for Survivors | Behavioral | — | UNRESOLVED |
| Standard Outreach for Close Relatives | Behavioral | — | UNRESOLVED |
| Standard Outreach for Survivors | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- Message-based Outreach Intervention (MBI) for Survivors
- description
- Cancer survivors randomized to receive a targeted letter with a unique website login code, access to the expanded website, free genetic counseling, and short message service (SMS) reminders.
- interventionNames
- Behavioral: Message-based Outreach Intervention for Survivors
- type
- ACTIVE_COMPARATOR
- label
- Standard Outreach for Survivors
- description
- Cancer survivors randomized to receive the standard outreach consisting of a standard letter with website access, access to a condensed version of the study website, and free genetic counseling.
- interventionNames
- Behavioral: Standard Outreach for Survivors
- type
- EXPERIMENTAL
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria for Survivors: * in the Georgia Cancer Registry (GSR) * diagnosed with ovarian, fallopian tube, or peritoneal cancers * lived in Georgia at the time of diagnosis * not deceased per the registry's records * have a mailing address in GSR records Inclusion Criteria for Close Relatives: * 25 years or older * able to access the internet * a 1st or 2nd degree relative of the survivor * able to read English * non-incarcerated or institutionalized Exclusion Criteria: * none
References
Publications (2)
- RESULTGuan Y, McBride CM, Zhao J, Pentz RD, Escoffery C, Liu Y, Cao Y, An W, Shepperd JA, Ward KC. Testing a Population-Based Outreach Intervention for Ovarian Cancer Survivors to Encourage their Close Relatives to Consider Genetic Counseling. Cancer Epidemiol Biomarkers Prev. 2024 Sep 3;33(9):1185-1193. doi: 10.1158/1055-9965.EPI-24-0147. PMID 38912902
- DERIVEDShepperd JA, McBride CM, An W, Zhao J, Pentz RD, Escoffery C, Ward K, Guan Y. Trust and Privacy Concerns Among Cancer Survivors Who Did Not Visit a Research Website Offering Free Genetic Counseling Services for Families: Survey Study. J Med Internet Res. 2025 May 6;27:e64228. doi: 10.2196/64228. PMID 40327861