Chiauranib Plus Weekly Paclitaxel in Patients with Platinum-refractory or Platinum-resistant Recurrent Ovarian Cancer

Inclusion Criteria:

* Willingness to sign a written informed consent document .
* Female, age ≥18 yrs and ≤70 yrs.
* Histological or cytological confirmation of epithelial ovarian cancer, carcinoma tube, or primary peritoneal carcinoma.
* Patients with platinum refractory or platinum resistant ovarian cancer:

  * Platinum refractory: progression during the first platinum-based treatment or within 4 weeks after the first platinum-based primary therapy;
  * Platinum resistant: progression during the platinum-based treatment except for platinum refractory, or within 6 months after the last receipt of platinum-based treatment (patients have received platinum containing chemotherapy at least 4 weeks);
  * Radiological progression during the last treatment administered;
  * no more than 1 prior treatment regimens for recurrent disease.
* Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1.
* At least 1 lesion can be accurately measured, as defined by RECIST1.1.
* Laboratory criteria are as follows:

  * Complete blood count: hemoglobin (Hb) ≥90g/L ; absolute neutrophil count (ANC) ≥1.5×109/L ; platelets ≥90×109/L;
  * Biochemistry test: serum creatinine(cr) \<1.5×ULN; total bilirubin\<1.5×ULN; alanine aminotransferase(ALT) ,aspartate aminotransferase(AST)≤2.5×ULN; (ALT,AST≦5×ULN if liver involved) ;
  * Coagulation test: International Normalized Ratio (INR) \< 1.5, activeated partial thromboplasting time (APTT) \<1.5×ULN
* Life expectancy of at least 3 months.

Exclusion Criteria:

* Patients received vascular endothelial growth factor(VEGF)/vascular endothelial growth factor receptor(VEGFR) inhibitor, like Apatinib, Anlotinib, Fruquintinib, Bevacizumab, etc., or Aurora kinase inhibitors.
* Patients received weekly paclitaxel therapy.
* Has known allegies to Chiauranib, paclitaxel or any of the excipients.
* Biological therapy, immunotherapy, hormonal therapy within 28 days prior to the first dose of study drug.
* prior major surgery or trauma within 14 days prior to first dose of study drug and/or presence of any non-healing wound, fracture, or ulcer.
* Treatment with an investigational agent/instrument within 28 days prior to first dose of study drug.
* Any ongoing toxicity from prior anti-cancer therapy that is \>Grade 1.
* Patients with prior invasive malignancies in the past five years with the exception of curatively-treated basal cell or squamous cell carcinoma of the skin or cervical carcinoma in situ.
* History or clinical evidence of central nervous system (CNS) metastases or leptomeningeal carcinomatosis.
* clinically significant central/peripheral nervous system disease.
* Have uncontrolled or significant cardiovascular disease, including:

  * Congestive heart failure, unstable angina pectoris, myocardial infarction within 6 months prior to study entry; arrhythmia, or Left Ventricular Ejection Fraction (LVEF) \< 50% requiring treatment with agents during screening stage.
  * primary cardiomyopathy(dilated cardiomyopathy, hypertrophic cardiomyocyte, arrhythmogenic right ventricular cardiomyopathy, restrictive cardiomyopathy, et,al)
  * History of significant QT interval prolongation, or Corrected QT Interval (QTc) \> 470 ms prior to study entry
  * Symptomatic coronary heart disease requiring treatment with agents
  * History of hypertension treated by≥2 agents, or the Blood pressure (Bp) ≥140/90 mmHg prior to study entry.
  * Other condition investigator considered inappropriate
* Significant intravenous or arterial thrombosis, such as cerebrovascular accident, pulmonary embolism or untreated deep venous thrombosis (DVT) within the past 6 months.
* History of active bleeding within the past 2 months, patients with bleeding potential during the screening period, or receiving anticoagulation therapy.
* CT or MRI of the chest during the screening period shows interstitial lung disease or pulmonary fibrosis or lung inflammation that requires treatment, or within 6 months before the first dose, history of pneumonia requiring oral or intravenous steroid treatment, history of immune-associated pneumonia after treatment of PD1/PDL1 inhibitor.
* Have clinical significant gastrointestinal abnormality that would impair the ingestion, transportation or absorption of oral agents, history of gastrointestinal perforation or abdominal fistula, peptic ulcer disease within 6 months prior to first dose of study drug or GI obstruction within the past 3 months.
* Pleural fluid, ascites or pericardial effusion with significant symptoms or required treatment of puncture or drainage during the screening period, or history of drainage for therapy within 1 months prior to first dose of study drug.
* Screening for HIV antibody positive.
* Screening test for hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb) positive with virus replication, hepatitis C antibody (HCV-Ab) positive with virus replication.
* Active infection requiring oral or intravenous systemic antimicrobial therapy during the screening period.
* Any mental or cognitive disorder, that would impair the ability to understand the informed consent document, or the compliance of study.
* History of organ transplantation or allo-HSCT.
* Any mental or cognitive disorder, that would impair the ability to understand the informed consent document, or the compliance of study.
* Candidates with drug and alcohol abuse.
* Participants of reproductive potential not willing to use adequate contraceptive measures for the duration of the study.Pregnant or breastfeeding women.
* Any other condition which is inappropriate for the study in the opinion of the investigators.