Clinical trial · Observational
Prediction of the Response to Neoadjuvant Radiation Chemotherapy Through Texture Analysis Derived From Medical Imaging
Prediction of the Response to Neoadjuvant Radiation Chemotherapy Through Texture Analysis Derived From Magnetic Resonance Imaging, Contrast Injection Computed Tomography and Positron Emission Tomography at 18-FDG in Locally Advanced Rectal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In patient with complete pathological response, surgery could be omitted without compromising progression-free or overall survival. A powerful prediction model is needed to guide management of this population. Radiomics features provide complementary information about tumor heterogenity. The aim of the investigators is to develop a model combining clinical and radiomic criteria able to predict complete pathological response.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- training population
- description
- patients from which we will develop the prediction model
- label
- testing population
- description
- patients on whom we will test the prediction model
Primary outcomes (1)
- measure
- Prediction of the complete response (pCR) to neoadjuvant chemoradiotherapy
- timeFrame
- TO = Immediately after biopsy and extension evaluation.
- description
- defined as the absence of tumor residue on the surgical specimen, ypT0N0
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * locally advanced rectal cancer * patients who received concomitant radio-chemotherapy followed by surgery * pre-therapeutic MRI and CT-scan dicom available Exclusion Criteria: * age under 18 yo * lack of MRI or CT-scan
References
Publications (0)
Data not yet available