MRI-based Approaches for Multi-parametric Model to Early Predict Pathological Complete Response to Neoadjuvant Therapy in Breast Cancer

1. For training cohort:

   Inclusion Criteria:
   * Age ≥18 years;
   * Histologically confirmed invasive breast carcinoma;
   * Clinical stage II-III at presentation;
   * Complete basic information and image data;
   * Have MRI imaging data at baseline and after the first cycle of NAC;
   * Finish the standard NAC treatment and undergo surgery;

   Exclusion Criteria:
   * With chemotherapy contraindications;
   * Multifocal of multicentric lesions;
   * Poor quality of MRI images;
2. For validation cohort:

Inclusion Criteria:

* Age ≥18 years;
* Complete basic information and image data;
* Clinical stage II-III at presentation;
* Scheduled for neoadjuvant chemotherapy;
* Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
* Signed informed consent;

Exclusion Criteria:

* With chemotherapy contraindications;
* Metastatic breast cancer;
* Multifocal of multicentric lesions;