Clinical trial · Interventional
HOPE-Genomics Intervention for the Improvement of Cancer Patient Knowledge of Genomics
Helping Oncology Patients Explore-Genomics (HOPE-Genomics) Web Tool Randomized Clinical Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 12, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260912-000001
Summary
Brief summary (as posted)
This clinical trial studies the effectiveness of a web-based cancer education tool called Helping Oncology Patients Explore Genomics (HOPE-Genomics) in improving patient knowledge of personal genomic testing results and cancer and genomics in general. HOPE-Genomics is a web-based education tool that teaches cancer/leukemia patients, and patients who may be at high-risk for developing cancer, about genomic testing and provide patients with information about their own genomic test results. The HOPE-Genomics tool may improve patient's genomic knowledge and quality of patient-centered care. In addition, it may also improve education and care quality for future patients.
Conditions
Conditions (7)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Carcinoma | Breast Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Colorectal Carcinoma | Colorectal Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Lung Carcinoma | Lung Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Malignant Solid Neoplasm | Malignant Solid Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Ovarian Carcinoma | Ovarian Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Pancreatic Carcinoma | Pancreatic Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Prostate Carcinoma | Prostate Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Best Practice | Other | — | UNRESOLVED |
| Educational Intervention | Other | — | UNRESOLVED |
| Genomic Profile | Procedure | — | UNRESOLVED |
| Survey Administration | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- Arm I (usual care)
- description
- Patients receive education pamphlet about WES and have their genomics test results returned by their clinician in a typical manner.
- interventionNames
- Other: Best Practice
- Other: Survey Administration
- type
- EXPERIMENTAL
- label
- Arm II (genomics test results, HOPE-Genomics)
- description
- Patients receive their genomics test results both from their clinician and from the HOPE-Genomics tool. Patients then view HOPE-Genomics tool over 15-20 minutes after their results are available.
- interventionNames
- Other: Educational Intervention
- Procedure: Genomic Profile
- Other: Survey Administration
- type
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Are enrolled in City of Hope (COH) Institutional Review Board (IRB) 07047 * Have a diagnosis of lung, breast, colorectal, pancreatic, ovarian or prostate cancer * Having somatic, germline or paired somatic/germline sequencing * Are fluent in English * Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 * Are \>= 18 years old Exclusion Criteria: * Are unable to provide informed consent
References
Publications (1)
- DERIVEDSolomon IB, Luong M, Currey M, Labib S, Tang S, Martinez J, Suarez C, Qiao R, Mak A, Cheung F, Manookian R, Xiao Y, Garcia M, Seshadri A, Jinadu J, Kim M, Martinez R, White P, Martinez F, Rout R, Sharifara A, Zhou C, Boyd P, Davey S, Gray SW. Rationale and study design for a randomized clinical trial of HOPE-Genomics, a web-based intervention to improve cancer patients' understanding of genomic testing results. Contemp Clin Trials. 2026 Aug;167:108358. doi: 10.1016/j.cct.2026.108358. Epub 2026 May 30. PMID 42217668