Clinical trial · Interventional
The DISSECT Study: Effect of Peri-aDventItial SMA diSsECtion on Margin sTatus During Pancreaticoduodenectomy for Resectable Pancreatic Cancer
Effect of Peri-adventitial SMA Dissection on Margin Status During Pancreaticoduodenectomy for Resectable Pancreatic Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
There is a high rate of R1 resection following patients undergoing pancreaticoduodenectomy for pancreatic cancer. The most commonly positive margin is the SMA. Peri-adventitial dissection has been proposed as an effective method of achieving R0 margins. There is lack of standardisation of the proposed technique and no grade 1 evidence to support routine use of this technique. The goal of this randomised controlled trial is to investigate the role of routine peri-adventitial dissection on the SMA margin status.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreatic Adenocarcinoma | Pancreatic Adenocarcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| No Periadventitial dissection of the SMA | Procedure | — | UNRESOLVED |
| Periadventitial dissection of the SMA | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Periadventitial dissection
- description
- For the patients randomised for peri-adventitial dissection the right side of the SMA should be completely clear from lymphoneural tissue for at least 180 degrees on right side and from "angle" of the artery to the level of inferior border of the uncinate process.
- interventionNames
- Procedure: Periadventitial dissection of the SMA
- type
- ACTIVE_COMPARATOR
- label
- NO periadventitial dissection
- description
- For patients randomised to NO peri-adventitial dissection, the lymphoneural tissue around the SMA should be left intact
- interventionNames
- Procedure: No Periadventitial dissection of the SMA
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * All adult (≥ 18 years old) patients with a non-metastatic (based on NCCN definition) on imaging pancreatic tumour of the head or uncinate process treated with a pancreaticoduodenectomy Exclusion Criteria: 1. All paediatric patients (\< 18 years old) 2. Patients that cannot provide consent 3. All borderline, locally advanced and metastatic pancreatic tumours on imaging (based on NCCN criteria) 4. All patients with a cytological or histological diagnosis of cholangiocarcinoma, ampullary and duodenal carcinoma 5. All patients with benign disease or dysplasia with no evidence of malignancy
References
Publications (0)
Data not yet available