Tislelizumab Combined With Nab-paclitaxel and Gemcitabine for Recurrent Pancreatic Cancer

Inclusion Criteria:

* Patients with radiologically or histologically confirmed postoperative Recurrent Pancreatic Cancer
* Patients with at least one measurable lesion (according to RECIST 1.1 criteria);
* Have not received gemcitabine-based regimen after surgery
* No systemic treatment after diagnosis of recurrence
* ECOG score 0-1
* Expected survival ≥ 3 months;
* Liver function is essentially normal: absolute neutrophil count \> 1500/mm ³; platelet count \> 100,000/mm ³; creatinine less than 1.5 times the upper limit of normal or calculated creatinine clearance (CRCI) \> 45 mL/min; total bilirubin ≤ 2.0 mg/dL; aspartate aminotransferase (AST) and alanine aminotransferase less than 2.5 times the upper limit of normal
* Appropriate to participate in this trial as assessed by the investigator before entering the study
* Male and female subjects of childbearing potential must agree to use an effective method of contraception throughout the study
* Signed Informed Consent Form

Exclusion Criteria:

* Patients who only undergo abdominal laparotomy but do not undergo resection of pancreatic tumor tissue
* Received gemcitabine-based regimen after surgery
* Systemic treatment after diagnosis of recurrence
* Patients with previous allergic reactions to similar drugs
* Pregnant or lactating patients
* Presence of pericardial effusion, uncontrolled pleural effusion, or clinically significant ascites at screening (including detectable ascites or ascites requiring puncture and aspiration on physical examination at screening)
* History of interstitial lung disease, pneumonitis, or uncontrolled systemic disease, including diabetes, hypertension, pulmonary fibrosis, acute lung disease, etc
* Patients with severe cardiovascular diseases within 12 months before enrollment, such as symptomatic coronary heart disease, ≥ grade II congestive heart failure, uncontrolled arrhythmia, myocardial infarction, etc
* Presence of any active immunodeficiency or autoimmune disease and/or history of any immunodeficiency or autoimmune disease that may recur at screening (e.g., hypothyroidism or hyperthyroidism, interstitial pneumonia, enteritis, hepatitis, hypophysitis, vasculitis, myocarditis, etc)
* Use of steroids or other systemic immunosuppressive therapy 14 days prior to enrollment
* Patients with other previous malignancies who are not cured
* Immunodeficient patients, such as HIV-positive
* Uncontrollable psychosis