Clinical trial · Observational
Multimodal Assesment of Acute Cardiac Toxicity Induced by Thoracic Radiotherapy in Cancer Patients
NCT04896242CI-TRIAL-00075702completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to evaluate and compare the changes by two modalities: Imaging by Strain by Speckle Tracking and Magnetic Resonance versus soluble markers of cardiac dysfunction as early predictors of cardio-toxicity in cancer patients receiving low or high doses of radiotherapy.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Cardiotoxicity | — | UNRESOLVED | — |
| Esophageal Cancer | Malignant Esophageal Neoplasm | CURATED_EXACT | 0.92 |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Radiotherapy; Complications | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Global Longitudinal Strain (Left Ventricle)
- timeFrame
- Baseline, 1 and 12 weeks after Treatment
- description
- \>5 Absolute drop or 12% Relative reduction from baseline
Secondary outcomes (4)
- measure
- Cardiac Magnetic Resonance Cinema Imaging
- timeFrame
- Baseline, 1 and 12 weeks after treatment
- description
- Cinema imaging: Long axis balance, Balance 4 cameras, Short shaft full balance, Right ventricular balance
- measure
- Cardiac Magnetic Resonance Anatomical Image
- timeFrame
- Baseline, 1 and 12 weeks after treatment
- description
- Inversion recovery single shot balance 3D short axis covering the entire heart and aorta with free respiratory trigger
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * ≥18 year-old patients * With histologically confirmed thoracic cancer (breast, esophagus or lung) * Recommendation of thoracic radiotherapy (RT) with curative intent * With or without chemotherapy * All patients must be able to read and understand Spanish * All patients must sign informed consent form. Exclusion Criteria: * Patients with no medical records, * Pregnant * Previously diagnosed with severe left ventricular dysfunction or a cardiac insufficiency * Patients with metastatic disease and indication of palliative RT * Patients with significant comorbidities associated to a \<5 year life expectancy. * Patients previously treated with thoracic RT
References
Publications (0)
Data not yet available
No reference posted for this study.