Clinical trial · Observational
The Effect of Anesthesia on Systemic Inflammatory Immune Index in Major Abdominal Cancer Surgeries
The Effect of Inhalation Anesthesia and Total Intravenous Anesthesia on Systemic Inflammatory Immune Index in Major Abdominal Cancer Surgeries
NCT04891146CI-TRIAL-00051847completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The effects of different anesthesia methods on the immune system are variable. In this study, we investigated the effect of inhalation anesthesia and total intravenous anesthesia on the SII value in major abdominal cancer surgeries.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer Gi | — | UNRESOLVED | — |
| Cancer of Endometrium | — | UNRESOLVED | — |
| Systemic Immune Activation | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Systemic inflammatory immmune index | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Inhalation anesthesia
- description
- Sevoflurane for opioid remifentanyl used
- interventionNames
- Other: Systemic inflammatory immmune index
- label
- Total Intravenous Anesthesia
- description
- Propofol for opioid remifentanyl used
- interventionNames
- Other: Systemic inflammatory immmune index
Primary outcomes (1)
- measure
- investigate the effect of anesthesia management on the change of preoperative systemic inflammatory immune index(SII) and postoperative 2.hour and 24.hour SII value
- timeFrame
- preoperative SII noted, postoperative 2.hour noted and postoperative 24.hour noted
- description
- systemic inflammatory immune index calculated by (platelet x neutrophil)/lymphocyte
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: * major abdominal cancer surgeries Exclusion Criteria: * blood transfusion in last 72 hours * patients with infection * hematologic malignancy * patient controlled analgesia
References
Publications (2)
- RESULTHu B, Yang XR, Xu Y, Sun YF, Sun C, Guo W, Zhang X, Wang WM, Qiu SJ, Zhou J, Fan J. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014 Dec 1;20(23):6212-22. doi: 10.1158/1078-0432.CCR-14-0442. Epub 2014 Sep 30. PMID 25271081
- RESULTLee JH, Kang SH, Kim Y, Kim HA, Kim BS. Effects of propofol-based total intravenous anesthesia on recurrence and overall survival in patients after modified radical mastectomy: a retrospective study. Korean J Anesthesiol. 2016 Apr;69(2):126-32. doi: 10.4097/kjae.2016.69.2.126. Epub 2016 Mar 30. PMID 27066202