Clinical trial · Interventional
Vestibular Precision: Physiology & Pathophysiology
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This project will investigate the role of noise in the vestibular system, and in particular its effects on the variability (precision) of vestibular-mediated behaviors. The investigators will study vestibular precision in normal subjects and patients with peripheral vestibular damage, and will investigate its potential plasticity. The goals are to develop a better understanding of the role noise plays in the vestibular system in normal and pathologic populations, and to determine if the brain can learn to improve signal recognition within its inherently noisy neural environment, which would result in improved behavioral precision.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Dizziness | — | UNRESOLVED | — |
| Inner Ear Disease | — | UNRESOLVED | — |
| Neurofibromatosis 2 | — | UNRESOLVED | — |
| Vestibular Disorder | — | UNRESOLVED | — |
| Vestibular Schwannoma | Vestibular Schwannoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| VOR precision training | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Normal Controls
- description
- normal control participants - no history of neurologic or inner ear disease
- interventionNames
- Behavioral: VOR precision training
- type
- EXPERIMENTAL
- label
- Peripheral Vestibular Dysfunction
- description
- Patients with unilateral vestibular damage due to monophasic illness such as vestibular neuritis or vestibular schwannoma (VS). For VS patients, the investigators will test them in three states: pre-op, sub-acute post-op (6 weeks), and chronic post-op (6 months).
- interventionNames
- Behavioral: VOR precision training
Primary outcomes (3)
- measure
- Change in perceptual thresholds
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 8 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: Normal subjects: * normal vestibular-oculomotor exams * normal low-frequency standard rotational testing * normal hearing Vestibular Schwannoma: * existence of unilateral vestibular schwannoma (pre \& post surgical resection) * must have sub-occipital surgical approach with complete sectioning of the vestibular nerve * rotational testing to assess pre-surgical vestibular function * audiogram * brain MRI consistent with vestibular schwannoma * audiography in each ear Exclusion Criteria: Normal subjects * history of otologic or neurologic disease * on vestibular suppressant medication (benzodiazepine, antihistamine, anticholinergic) Vestibular Schwannoma * other otologic disease (other than presbycusis) or any neurologic disease (other than migraine) * on vestibular suppressant medication (benzodiazepine, antihistamine, anticholinergic)
References
Publications (0)
Data not yet available