Clinical trial · Interventional
Screening More Patients for Colorectal Cancer Through Adapting and Refining Targeted Evidence-Based Interventions in Rural Settings, SMARTER CRC
Screening More Patients for CRC Through Adapting and Refining Targeted Evidence-Based Interventions in Rural Settings (SMARTER CRC)
NCT04890054CI-TRIAL-00093822SMARTER CRCcompletedN/AResults postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study collects information to provide a model for how to rapidly adapt and scale-up multilevel interventions through clinic-health plan partnerships to reduce the burden of colorectal cancer (CRC) on the United states population. This study may improve colorectal cancer screening rates, follow-up colonoscopy, and referral to care in rural Medicaid patients.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Carcinoma | Colorectal Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Fecal Immunochemical Test | Other | — | UNRESOLVED |
| Interview | Other | — | UNRESOLVED |
| Patient Navigation | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- SMARTER CRC Intervention Year 1
- description
- In year 1, patients receive mailed FITs from CCO, screening reminders from clinics, and patient navigation as appropriate; Health record data collected.
- interventionNames
- Other: Fecal Immunochemical Test
- Other: Interview
- Behavioral: Patient Navigation
- type
- NO_INTERVENTION
- label
- SMARTER CRC Usual Care
- description
- Usual clinical care
Primary outcomes (1)
- measure
- Likelihood of Any Colorectal Cancer (CRC) Screening (for Study-eligible Patients)
- timeFrame
- Primary outcome at 6 months following CCO eligible patient list pull date,
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * CCOs/CCO STAFF: Serving a majority of counties that are predominantly rural based on 2010 Rural-Urban Commuting Area (RUCA) codes (codes 4-10) * CCOs/CCO STAFF: Willing to participate in data collection activities (e.g., producing claims data, interviews) * CLINICS: Clinics will be eligible for the cluster randomization if there are 30 or more patients eligible for screening * CLINICS: Are classified as rural according to RUCA (Codes 4-10) or Oregon Office of Rural Health designations * CLINICS: Are served by CCOs agreeing to participate in the project * CLINICS: Willing to implement the intervention into their clinic for the study * CLINIC STAFF/PROVIDERS: Employed as a clinician or ancillary staff member in a participating clinic * CLINIC STAFF/PROVIDERS: Willing to participate in data collection activities (e.g., interviews, observation, surveys) * PATIENTS: Attributed to participating clinic * PATIENTS: Are enrolled in Medicaid or dual eligible * PATIENTS: Eligible for colorectal cancer (CRC) screening * PATIENTS: For the subset of patients that will be invited to participate in key informant interviews, a 5th eligibility criteria is consented to participate * COMMUNITY OR REGIONAL/ORGANIZATIONAL PARTNERS: (Includes endoscopy providers, community-based outreach workers, or leaders from regional or national organizations who participate in the pilot, pragmatic trial, or scale-up study) * COMMUNITY OR REGIONAL/ORGANIZATIONAL PARTNERS: Involved in study activities (training, care delivery) * COMMUNITY OR REGIONAL/ORGANIZATIONAL PARTNERS: Willing to participate in data collection activities (e.g., trainings, interviews, surveys) * Elderly - Yes - we anticipate that a limited number of clinic and CCO staff, or community organization representatives may be elderly; we limit our patient recruitment to those aged 45-75 * Rural - Yes * Inner city - No * Low income - Yes * Disabled - Yes * Chronic care - Yes * End of life - Yes - This is possible, but we predict limited numbers because of the types of individuals we are recruiting: clinic and CCO staff, and patients who are not currently in hospice care * Minorities - Yes Exclusion Criteria: * CLINICS: Clinics are excluded if they have current or ongoing participating in other mailed fecal testing research projects in the Medicaid population * PATIENTS: Are current for screening * PATIENTS: Comorbid conditions that make patients poor candidates for screening based on clinical judgment (e.g., end-stage renal disease, enrollment in hospice) * PATIENTS: Are not an established patient or for other reasons documented by the clinics * All patients that we recruit will be at least 45 years of age or older
References
Publications (5)
- DERIVEDKenzie ES, Herreid-O'Neill A, Myers E, Coury J, Badicke B, Coronado G, Davis MM. Facilitation of Health Plan-Clinic Partnerships to Improve Colorectal Cancer Screening for Rural Medicaid Enrollees: A Qualitative Study. J Rural Health. 2026 Jun;42(3):e70203. doi: 10.1111/jrh.70203. PMID 42572815
- DERIVEDCurrier JJ, Coury J, Myers E, Kenzie ES, Petrik AF, Badicke B, McDonnell MM, Abbott MC, Coronado GD, Davis MM. Scale-up evaluation results of a multi-level approach using mailed immunochemical test (FIT) and patient navigation to increase colorectal cancer screening rates in rural clinic settings. BMC Prim Care. 2026 Jul 14. doi: 10.1186/s12875-026-03428-w. Online ahead of print. PMID 42449237
- DERIVEDCoronado GD, Petrik AF, Leo MC, Coury J, Durr R, Badicke B, Thompson JH, Edelmann AC, Davis MM. Mailed Outreach and Patient Navigation for Colorectal Cancer Screening Among Rural Medicaid Enrollees: A Cluster Randomized Clinical Trial. JAMA Netw Open. 2025 Mar 3;8(3):e250928. doi: 10.1001/jamanetworkopen.2025.0928. PMID 40094661
- DERIVEDCoury J, Coronado G, Currier JJ, Kenzie ES, Petrik AF, Badicke B, Myers E, Davis MM. Methods for scaling up an outreach intervention to increase colorectal cancer screening rates in rural areas. Implement Sci Commun. 2024 Jan 8;5(1):6. doi: 10.1186/s43058-023-00540-1. PMID 38191536
- DERIVEDCoronado GD, Leo MC, Ramsey K, Coury J, Petrik AF, Patzel M, Kenzie ES, Thompson JH, Brodt E, Mummadi R, Elder N, Davis MM. Mailed fecal testing and patient navigation versus usual care to improve rates of colorectal cancer screening and follow-up colonoscopy in rural Medicaid enrollees: a cluster-randomized controlled trial. Implement Sci Commun. 2022 Apr 13;3(1):42. doi: 10.1186/s43058-022-00285-3. PMID 35418107