GIST and Memory and Attention Adaptation Training

Inclusion Criteria:

1. Age 18 and above;
2. Diagnosis of Gastrointestinal stromal tumor (GIST);
3. At least 1 year post-initiation of TKI therapy;
4. Report cognitive problems of memory and concentration attributed to GIST and/or treatment with a score of 10 or below on the FACT-Cog Impact on Quality of Life Scale;
5. Able to speak and read English;
6. Able to provide IRB-approved written informed consent; and
7. Willingness to use videoconferencing and complete phone-based neurocognitive assessments

Exclusion Criteria:

1. Previous treatment with a tyrosine kinase inhibitor medication for a non-GIST diagnosis
2. Previous CNS radiation, intrathecal therapy, or CNS-involved surgery;
3. Previous cancer history with the exception of non-melanoma skin cancer;
4. Previous exposure to chemotherapy with another cancer or due to other medical condition (e.g., methotrexate exposure for treatment of rheumatoid arthritis);
5. Scoring 3 or below on the 6-item cognitive screen designed to detect severe memory disorders;1
6. Significant neurodevelopmental, neurobehavioral, or medical risk factors likely to affect cognitive functioning (e.g., history of neurological disorder, stroke, traumatic brain injury greater than mild severity, such as loss of consciousness \>30 minutes, medical disorder that is unstable or likely to affect cognition such as metabolic disorder, heart attack, uncontrolled diabetes or endocrine dysfunction);
7. Current severe DSM-5 mental disorder criteria, including but not limited to neurodevelopmental, substance abuse, mood, anxiety, or psychotic disorders