Clinical trial · Observational
Tissue Engineering Approaches to Treat COPD
A Tissue Engineering Approach to Improve Lung Function and Clinical Outcome in Patients With COPD
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The study is a pilot/laboratory study comparing lung tissue from control participants with tissue from COPD participants with a chronic bronchitis or emphysema phenotypes. Tissue will be characterised mechanically and biochemically. Lung cells, including DASCp63/Krt5 with a possible role in disease pathology, will be isolated, expanded in vitro, characterised, and banked. Biomaterials will be selected and tested with regards to mechanical and physical properties and selected for use in the production of TELEs with properties matched to healthy and diseased lung tissue. The resulting TELEs will be tested in an ex vivo tissue culture model to determine the extent of their integration with lung.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Patients undergoing standard surgery, excess tissue only will be analysed with patient consent. | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Cohort A: 10 participants with no COPD
- description
- Control patients Have no physician diagnosis of COPD Have no other significant chronic lung disease (asthma, fibrotic diseases) or ongoing lung infection other than the suspected cancer for which they have been referred for surgery. Lifelong never-smokers or ex-smokers (\< 10 pack years). (1 pack year= 20 cigarettes/day for 1 year).
- interventionNames
- Procedure: Patients undergoing standard surgery, excess tissue only will be analysed with patient consent.
- label
- Cohort B: 10 participants with COPD - chronic bronchitis
- description
- Have a physician diagnosis of COPD with primarily a chronic bronchitis presentation (determined via CT, spirometry, histopathology, GOLD COPD classification).
- interventionNames
- Procedure: Patients undergoing standard surgery, excess tissue only will be analysed with patient consent.
- label
- Cohort C: 10 participants with COPD emphysema
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Men or women aged over 18 years- . * Must be competent to give written informed consent. * Scheduled to undergo clinical indicated surgery to remove lung tissue. Exclusion Criteria: * Patient unable to give informed consent * Significant long term condition or lung pathology (infection, asthma, fibrotic lung diseases) other than that for which they have been referred for surgery. Post Surgery • Insufficient tissue removed to supply the laboratory study after consultation with the Consultant histopathologist.
References
Publications (0)
Data not yet available