Clinical trial · Interventional
GLP-1 RAs in Patients With Polycystic Ovary Syndrome (PCOS)
Dulaglutide and Calorie Restrict Diet (CRD) in Overweight/Obese Patients With Polycystic Ovary Syndrome
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Polycystic ovary syndrome (PCOS) is a common endocrine disorder, with a prevalence of 5% to 15% in premenopausal women. Patients with PCOS presents as abnormal menstruation, ovulation disorders and/or hyperandrogenemia, and often accompanied by insulin resistance and other metabolic abnormalities. Visceral fat dysfunction is an important factor in the onset of PCOS. GLP-1 receptor agonist is a glucagon-like peptide 1 analog, which is related to improving blood sugar control, weight loss and appetite suppression, and reducing cardiovascular risk. The purpose of this study was to compare whether the combined treatment of GLP-1 receptor agonists and calorie restrict diet reduced more visceral fat of overweight/obese patients with PCOS at the same weight loss (7%) compared with calorie restrict diet alone.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Polycystic Ovary Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| calorie restricted diet | Other | — | UNRESOLVED |
| GLP-1 RAs | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- GLP-1 RAs and calorie restrict diet group
- description
- Intervention with GLP-1 RAs and calorie restrict diet until reaching the target weight loss(7%)
- interventionNames
- Drug: GLP-1 RAs
- Other: calorie restricted diet
- type
- ACTIVE_COMPARATOR
- label
- calorie restrict diet group
- description
- Intervention with calorie restrict diet until reaching the target weight loss(7%)
- interventionNames
- Other: calorie restricted diet
Primary outcomes (1)
- measure
- the change in visceral adipose tissue
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 45 Years
Show eligibility criteria text
Inclusion Criteria: * Female aged 18- 45; * Meet 2003 Rotterdam criteria; * overweight/obesity,BMI≥24kg/m2. Exclusion Criteria: * any contraindication to dulaglutide (known or suspected hypersensitivity to dulaglutide or related products, previous acute pancreatitis or chronic pancreatitis, inflammatory bowel disease; personal history or family history of medullary thyroid carcinoma, or personal history of multiple endocrine neoplasia type 2)； * treatment with any other drugs that may interfere with the trial, including traditional Chinese medicine, contraceptives, metformin, GLP-1RA or pioglitazone within the last 3 months； * chronic kidney disease or severe liver dysfunction； * malignant tumors； * mental illness; * pregnancy or lactation； * inflammatory bowel disease; * recent participation in other weight-loss research projects within the last 3 months.
References
Publications (0)
Data not yet available