Clinical trial · Observational
Diagnostic and Prognostic Value of PTEN Expression in Functional and Pathological Endometrial Biopsies
Diagnostic and Prognostic Value of PTEN Expression in Functional and Pathological Endometrial Biopsies.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
endometrial hyperplasia may progress to endometrial adenocarcinoma. the exact possibility of such progression is not determined. there a need to detect biological markers that can help in detecting high risk cases of patients with endometrial hyperplasia that may progress to endometrial adenocarcinoma. PTEN is a tumor suppressor gene that inhibit cell migration, proliferation and may induce apoptosis in damaged cells. variable expression of PTEN in functional, hyperplastic and neoplastic endometrial tissues may be of great help in detecting cases of hyperplasia that may progress to endometrial adenocarcinoma.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Endometrial Adenocarcinoma | Endometrial Adenocarcinoma | CURATED_BROADER | 0.80 |
| Endometrial Hyperplasia | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| routine stain by H&E. | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Functional/ Cyclical Endometrial group.
- description
- cases of normal endometrium will be obtained from hystrectomy specimens done for causes other than hyperplasia or adenocarcinoma, for example; uterine fibroids, uterine prolapse.
- interventionNames
- Other: routine stain by H&E.
- label
- Hyperplastic Endometrial group.
- description
- cases of endometrial hyperplasia obtained by D\&C or hystrectomy will be stained by H\&E stain and categorized into typical or atypical hyperplasia.
- interventionNames
- Other: routine stain by H&E.
- label
- Primary Endometrial Adenocarcinoma group.
- description
- cases of primary endometrial adenocarcinoma obtained by D\&C or hystrectomy operations
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 15 Years
Show eligibility criteria text
Inclusion Criteria: * all cases of endometrial biopsies and hystrectomy specimens diagnosed as endometrial hyperplasia and/or primary endometrial adenocarcinoma. * all cases of normal endometrium obtained from hystrectomy specimens due to other pathological conditions as prolapsed uteri, uterine leiomyoma and adenomyosis. Exclusion Criteria: * autolysed samples, very tiny specimens cervical tissues and specimens with histological picture of endometritis.
References
Publications (0)
Data not yet available