Clinical trial · Interventional
Improving Detection and Early Action for HPV-positive Oropharynx Cancer
NCT04871490CI-TRIAL-00085537IDEA-HPVcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to determine whether a blood test for HPV DNA can improve diagnosis of HPV-positive oropharynx cancer (HPV-OPC).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| HPV Positive Oropharyngeal Squamous Cell Carcinoma | Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood test for HPV DNA | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Study Group
- description
- All eligible participants.
- interventionNames
- Diagnostic Test: Blood test for HPV DNA
Primary outcomes (1)
- measure
- Prevalence of circulating HPV DNA
- timeFrame
- Test results are returned within 1 week.
- description
- Proportion of participants with circulating HPV DNA detected in their blood.
Secondary outcomes (3)
- measure
- Predictive value of circulating HPV DNA
- timeFrame
- Long-term follow-up for up to 2 years
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 35 Years
Show eligibility criteria text
Inclusion Criteria: * Neck mass present for \>2 weeks with no signs/symptoms of infection * Neck mass present for \>2 weeks with signs/symptoms of infection that did not resolve with antibiotic therapy * Palatine or lingual tonsillar asymmetry on physical exam * Palatine or lingual tonsillar asymmetry on imaging, including asymmetric FDG uptake in palatine or lingual tonsils on PET-CT scans * Unexplained throat pain for \>2 weeks that did not resolve with antibiotic therapy Exclusion Criteria: * Known diagnosis of HPV-OPC
References
Publications (0)
Data not yet available
No reference posted for this study.