Clinical trial · Observational
Finding New Targets by Proteomic Approaches (InnovRT1)
Heterogeneity in Rhabdoid Tumors : Proteomic and Single-Cell Analyses to Identify New Therapeutic Targets
NCT04868799CI-TRIAL-00097585InnovRT1completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 26, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260926-000001
Summary
Brief summary (as posted)
The investigators aim to explore the inter tumor heterogeneity by a proteomic approach of a wide series of rhabdoid tumors, from both intra and extra cranial origins.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| ATRT | Atypical Teratoid/Rhabdoid Tumor | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Mass spectrometry | Biological | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- ATRT
- description
- Patients \<18 years with an ATRT having frozen samples
- interventionNames
- Biological: Mass spectrometry
Primary outcomes (1)
- measure
- Identification of proteomic signature for each molecular subgroup of ATRT
- timeFrame
- 3 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 17 Years
Show eligibility criteria text
Inclusion Criteria: * Aged 0-17 years old * Rhabdoid tumor, treated in oncology departments in Ile de France * frozen samples collected in usual care * parents' agreement for samples collection in usual care Exclusion Criteria * Unconfirmed diagnosis of Rhabdoid tumor with molecular analyses Samples * paraffin embedded tissues
References
Publications (1)
- RESULTLobon-Iglesias MJ, Andrianteranagna M, Han ZY, Chauvin C, Masliah-Planchon J, Manriquez V, Tauziede-Espariat A, Turczynski S, Bouarich-Bourimi R, Frah M, Dufour C, Blauwblomme T, Cardoen L, Pierron G, Maillot L, Guillemot D, Reynaud S, Bourneix C, Pouponnot C, Surdez D, Bohec M, Baulande S, Delattre O, Piaggio E, Ayrault O, Waterfall JJ, Servant N, Beccaria K, Dangouloff-Ros V, Bourdeaut F. Imaging and multi-omics datasets converge to define different neural progenitor origins for ATRT-SHH subgroups. Nat Commun. 2023 Oct 20;14(1):6669. doi: 10.1038/s41467-023-42371-7. PMID 37863903