Clinical trial · Observational
Radiation-induced Cardiac Toxicity After Non-small Cell Lung Cancer Radiotherapy
Radiation-induced Cardiac Toxicity After Non-small Cell Lung Cancer Radiotherapy Detected by Speckle-tracking Echocardiography
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Despite the growing interest in investigating how the radiotherapy (RT) dose to anatomical substructures of the heart links to survival, the heart substructures at risk remain poorly defined. They are not delineated routinely as part of the RT planning process and there is no consensus on their dose constrains. With improving prognosis for non-small cell lung cancer (NSCLC) patients, the evidence relating irradiation of the heart to excess mortality has begun to accumulate. The study aims to evaluate subclinical cardiac dysfunction in consecutive NSCLC patients treated with definitive RT and to investigate the predictive value of the heart substructures dosimetric parameters for subclinical and overt cardiac toxicity as assessed using traditional and speckle tracking echocardiography (STE). The study will also investigate whether subclinical alterations detected by echocardiography with strain imaging may serve as a marker for future clinical dysfunctions.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cardiac Toxicity | — | UNRESOLVED | — |
| Non-small Cell Lung Cancer | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
| Radiation Toxicity | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Echocardiography | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- NSCLC patients treated with curative radiotherapy
- description
- Consecutive NSCLC patients treated with standard RT with curative intent with or without platinum-based CHT
- interventionNames
- Diagnostic Test: Echocardiography
Primary outcomes (1)
- measure
- RT-induced systolic and diastolic function alterations
- timeFrame
- 1 year
- description
- Systolic and diastolic function alterations assessed using traditional echocardiographic parameters as well as speckle tracking echocardiography analysis at 1, 6, and 12 months after RT compared to baseline.
Secondary outcomes (3)
- measure
- The predictive value of cardiac substructures dosimetric parameters for cardiac toxicity as evaluated using STE and traditional echocardiographic parameters
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age 18 or older * Ability to provide informed consent * Histologically confirmed non-small cell carcinoma of the lung * Patient to receive standard RT with curative intent with or without concurrent or sequential CHT according to the institutional protocol * ECOG performance status 0-1 within one month of accrual * Negative pregnancy test within one month of accrual if woman is premenopausal * Patient presented at multidisciplinary tumor board or quality-assurance rounds * Satisfactory pulmonary function tests, i.e., forced expiratory volume during the first second (FEV1) ≥ 1.0 l (≥40%) Exclusion Criteria: * Noncompliance with any of the inclusion criteria * Pregnancy * Prior RT to the thorax * Patient to receive stereotactic body radiation therapy (SBRT)
References
Publications (0)
Data not yet available