Clinical trial · Observational
Pharmacotherapy Personalization of Cancer Patients
Pharmacotherapy Personalization of Cancer Patients Based on Modern Analytical and Computational Techniques
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Treatment personalization could ensure better outcome than standard procedures. It is particularly important in intensive care units where patients received many drugs and procedures. Their health status can change very fast. The oncologic patients treated in intensive care units are a special group of patients. Factors related to cancer influence extra their health status. The aim of this study is population pharmacokinetic-pharmacodynamic analysis drugs that are routinely used during an analgosedation in ICU oncologic patients. Analgosedation is monitored by drugs plasma concentration, the depth of sedation (bispectral index) and vital parameters like: systolic and diastolic blood pressure, mean arterial pressure, heart rate. Moreover, the TNM Staging System, biochemical parameters, The American Society of Anesthesiologists (ASA) physical status classification will be checked like potential factors influencing on pharmacokinetics and pharmacodynamics drugs used in the study.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Neoplasms | Head and Neck Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Oncologic Patients | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Infusion Intravenous | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Analgosedation in ICU patients after head and neck tumor resection in general anesthesia
- description
- Head and neck tumor resections were performed in general anesthesia. Midazolam and etomidate or propofol were used in introduction and then anesthesia was maintenance with sevoflurane. Patients received intravenous continuous infusion of oxycodone as an analgesic component and sedatives (propofol/dexmedetomidine/midazolam) during analgosedation in ICU.
- interventionNames
- Drug: Infusion Intravenous
Primary outcomes (1)
- measure
- Measurement of the depth of sedation using bispectral index
- timeFrame
- from the beginning of analgosedation to 6 hours after analgosedation
- description
- Continuous measurement of the depth of sedation using bispectral index during analgosedation in intensive care unit.
Secondary outcomes (8)
- measure
- Oxycodone plasma concentrations [ng/ml]
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * age over 18 years old, * qualifications to oncologic surgery, * needing of analgosedation in ICU after an operation Exclusion Criteria: * proven allergies to used in anesthetics or/analgosedation medicaments, * lack of written confirmed consent of a patient
References
Publications (0)
Data not yet available