Clinical trial · Interventional
Vitamin D and Pre Cachexia and Cancer Cachexia in Epithelial Ovarian Cancer
The Effect of Vitamin D on Factors Contributing Pre Cachexia and Cachexia, a Study on Epithelial Ovarian Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Several ex vivo, in vitro, and observational studies on various type of cancer shown positive effect of vitamin D. Vitamin D has widely known as immunomodulator property in various diseases. However, it remains limited studies on immunity and cachexia in cancer, particularly in ovarian cancer. This study will investigate the effect of vitamin D in immune response during chemotherapy among epithelial ovarian cancer patients who have a low level of vitamin D and cachexia
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Epithelial Ovarian Cancer | Ovarian Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Placebo | Other | — | UNRESOLVED |
| Vitamin D | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Vitamin D group
- description
- Daily vitamin D3 2000 IU on day 1 through day 180 Intervention: vitamin D3 2000 IU
- interventionNames
- Dietary Supplement: Vitamin D
- type
- PLACEBO_COMPARATOR
- label
- Control group
- description
- Daily placebo (saccharum lactis) on day 1 through day 180 Intervention: placebo
- interventionNames
- Other: Placebo
Primary outcomes (1)
- measure
- Rate of immune response in participants receiving vitamin D change from baseline as assessed by lymphocyte CD8
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: 1. age 18-60 years old who are newly diagnosed with ovarian cancer based on histopathology 2. epithelial ovarian cancer stage II-III 3. haven't received chemotherapy 4. pre-cachexia or cachexia 5. level of vitamin D below 30 ng/ml 6. no vitamin D allergy 7. ability and willingness to understand and provide informed consent Exclusion Criteria: 1. autoimmune disease 2. chronic liver disease 3. chronic renal disease 4. known had hypercalcemia 5. refractory cachexia
References
Publications (0)
Data not yet available