Clinical trial · Observational
Dynamic Evolution of Pulmonary Nodules and Influence Factors of Its Clinical Decision-making
Dynamic Evolution of Pulmonary Nodules and Influence Factors of Its Clinical Decision-making: A Prospective Cohort Study
NCT04857333CI-TRIAL-00064764DEPICTunknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The researchers are aimed to investigate the dynamic evolution of indeterminate pulmonary nodules by a long-term follow-up of patients with different characteristics. Influence factors of clinical decision-making that might contribute to overtreatment or delayed treatment will also be studied.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pulmonary Nodule, Multiple | — | UNRESOLVED | — |
| Pulmonary Nodule, Solitary | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Antibiotics | Drug | — | UNRESOLVED |
| CT scan | Diagnostic Test | — | UNRESOLVED |
| Surgical Resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Pulmonary Nodule
- description
- Patients are recommended for using antibiotics, solely follow-up or surgical resection according to the current clinical guideline for management of indeterminate pulmonary nodule. No intervention is administered for this observatory study.
- interventionNames
- Diagnostic Test: CT scan
- Drug: Antibiotics
- Procedure: Surgical Resection
Primary outcomes (2)
- measure
- Time to surgical resection
- timeFrame
- The date of first documented diagnosis of pulmonary nodule by CT scan to the date of surgical resection, up to 60 months
- description
- Time calculated from the date of identification of pulmonary nodule to the date of surgical resection
- measure
- Time to progression
- timeFrame
- The date of first documented diagnosis of pulmonary nodule by CT scan to the date of documented progression by CT scan, up to 60 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 14 Years
- Maximum age
- 85 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients with pulmonary nodules ≤ 3cm 2. Patients who provide electronic, written or oral consent to be enrolled in the follow-up cohort Exclusion Criteria: 1. Patients with a surgical history of pulmonary nodules; 2. Patients who have obtained pathological diagnosis through surgery or non-surgical methods such as puncture; 3. Patients with pulmonary nodules that are likely metastatic from other sites; 4. Refuse to participate in this study.
References
Publications (2)
- DERIVEDWu J, Zhuang W, Chen R, Xu H, Li Z, Lan Z, Xia X, He Z, Li S, Deng C, Xu W, Shi Q, Tang Y, Qiao G. Impact of surgery versus follow-up on psychological distress in patients with indeterminate pulmonary nodules: A prospective observational study. Qual Life Res. 2025 Apr;34(4):1167-1177. doi: 10.1007/s11136-024-03876-w. Epub 2025 Jan 15. PMID 39812961
- DERIVEDZhuang W, Tang Y, Xu W, Huang S, Deng C, Chen R, Zhang D, Zeng C, Tian D, Ben X, Lan Z, Wu H, Gao Z, Wang M, Chen Y, Shi Q, Qiao G. Should psychological distress be listed as a surgical indication for indeterminate pulmonary nodules: protocol for a prospective cohort study in real-world settings. J Thorac Dis. 2022 Mar;14(3):769-778. doi: 10.21037/jtd-21-1423. PMID 35399240