A Study Evaluating Safety and Therapeutic Activity of ANV419 in Patients with Advanced Cancer.

Inclusion Criteria:

* Ability of the patient or legal guardian to understand the purpose of the study, provide signed and dated informed consent from the patient prior to performing any protocol-related procedures (including Screening evaluations), and be able and willing to comply with the study procedures.
* Male or female aged ≥ 18 years.
* Advanced solid tumors with evidence of progressive disease as per RECIST no longer than 3 months before Informed Consent form (ICF) signature, without any subsequent curative intent treatment.
* Parts A and B only: Histologically confirmed relapsed/refractory advanced solid tumor, progressing after at least one line of treatment for advanced or metastatic disease
* Part C only: Previously treated advanced NSCLC without a driver mutation who have progressed after first line standard chemo-immunotherapy: Patients must have measurable disease using RECIST v1.1, A maximum of 1 line of therapy is permitted, Patients with high expression of PD-L1 which were treated with first line checkpoint inhibitor monotherapy may have received a maximum of 2 lines of therapy
* Part D only: Histologically confirmed relapsed/refractory advanced solid tumors progressing after at least one line of treatment for advanced disease. Patients with NSCLC who do not meet inclusion criteria for Part C, are eligible for Part D
* Eastern Cooperative Oncology Group (ECOG) Performance Status 0-1.
* Adequate pulmonary, cardiovascular, hematological, liver and renal function, per Investigator judgment.
* All acute toxic effects, of any prior anticancer therapy (e.g., radiotherapy, chemotherapy, or surgical procedures) must have resolved to CTCAE v5.0 grade ≤1 (except alopecia \[any grade\] or fatigue \[up to grade 2 allowed\]).
* Negative serum pregnancy test at screening and a negative (urine or serum) pregnancy test within 7 days prior to study day 1 in women of childbearing potential and women \<12 months after menopause.
* Women who are not postmenopausal and who have not undergone surgical sterilization: must agree to use highly effective methods of contraception during the treatment period and until 6 months after the last dose of study treatment. They must also agree to not donate eggs (ova, oocytes) during the same timeframe.
* All men with childbearing potential partners must agree to use highly effective methods of contraception and barrier contraception (condom) during the treatment period and for 6 months after the last dose of study treatment. They must also agree to not donate sperm during the same timeframe.
* Availability and willingness of patients to obtain a baseline and on treatment biopsy of the tumor. Available archived biopsies (frozen or formalin fixed) may serve as baseline specimens, in patients who have residual tumor masses which can only be accessed with significant risk

Exclusion Criteria:

* Carcinomatous meningitis and/or symptomatic central nervous system (CNS) metastases. Definitively treated CNS metastases (e.g., radiotherapy) stable for at least 6 weeks prior to Day 1 of study drug administration are acceptable.
* Participants with an active second malignancy. Patients with precancerous lesions, concomitant early stages of prostate or breast cancer not requiring active treatment (past conditions currently resolved \> 3 years prior to Screening are also acceptable), and squamous cell carcinoma of the skin not requiring systemic treatment are acceptable.
* Evidence of significant, uncontrolled concomitant diseases that could affect compliance with the protocol or interpretation of results, including uncontrolled diabetes mellitus, history of relevant pulmonary disorders, (e.g., severe bronchospasm, obstructive pulmonary disease), hyperthyroidism due to thyroiditis and known autoimmune diseases or other disease with ongoing fibrosis. Stable vitiligo, autoimmune thyroiditis, and preexisting treated type 1 diabetes are acceptable and are not exclusion criteria.
* Significant cardiovascular/cerebrovascular disease, including myocardial infarction or transient ischemic attack (TIA) within 6 months prior to Day 1 of study drug administration.
* Active infections, or uncontrolled infection requiring systemic antibiotics within one week (7 days) preceding Day 1 of treatment
* Hemoglobin (Hb) \<9 g/dL, transfusion of red blood cells allowed to reach threshold target.
* Neutrophils \<1500 /mm3.
* Platelets \<100'000/mm3.
* Liver: aspartate aminotransferase (AST) or alanine aminotransferase (ALT) \>2.5xULN, if due to liver metastasis or primary liver cancer, AST or ALT \>5x ULN.
* Total bilirubin \> upper limit of normal (ULN) (in documented Gilbert's syndrome, direct bilirubin \> ULN).
* International normalized ratio (INR) \>1.5xULN.
* Serum creatinine \> ULN and estimated creatinine clearance \< 50 mL/min using the Cockcroft-Gault formula.
* Confirmed replicating human immunodeficiency virus (HIV) or confirmed active (replicative) hepatitis B virus or hepatitis C virus infection. Patients with treated non-replicative disease are acceptable.
* Evidence of hepatic cirrhosis with Child-Pugh score C.
* Any other diseases, metabolic dysfunction, physical examination finding, or clinical laboratory finding \> Grade 2 that give reasonable suspicion of a disease or condition that would contraindicate the use of an investigational drug.
* Major surgery or significant traumatic injury \<28 days prior to the first ANV419 infusion (excluding biopsies) or anticipation of the need for major surgery during study treatment.
* Severe altered mental status.
* Pregnant or breastfeeding women.
* Known hypersensitivity to any of the components of ANV419 or its formulation.
* Concurrent therapy with any other investigational drug within one month prior to Day 1 of study drug administration.
* Active untreated immune-related endocrinopathies untreatable with replacement. Prior immune related toxicities \> Grade 3 after treatment with immunostimulatory drugs (e.g., colitis, neuropathy) that have not completely resolved.
* Chronic treatment with systemic immunosuppressive medications above 10 mg/day prednisolone equivalent for any reason.

Additional exclusion criteria for Part D:

* Experienced unacceptable drug-related toxicity with prior ipilimumab treatment (defined as toxicities that required second line immunosuppression, ie, not controlled by steroids alone)
* Received ipilimumab within 6 months prior to cycle 1 day 1.
* Known hypersensitivity to ipilimumab or any of its excipients
* Patients with active autoimmune disease or a history of autoimmune disease (other than vitiligo and adequately controlled endocrine deficiencies such as hypothyroidism),
* Symptomatic interstitial lung disease
* Concomitant use of therapeutic anti-coagulation (e.g.to treat pulmonary embolus or deep vein thrombosis). Prophylactic anti-coagulation is permitted.