Clinical trial · Observational
Tissue Collection for Drug Screening and Bioanalysis
NCT04852354CI-TRIAL-00099174recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to improve upon the knowledge currently available about central nervous system (CNS) tumors. We will study the different characteristics of these tumors using tissue samples collected during surgery and post-autopsy. The aim is to create tumor cell lines and models to test how they respond to different drugs. This research will help improve treatment options and identify new targets for therapy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Central Nervous System Tumor | Central Nervous System Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (4)
- label
- Cohort 1: Tumor patients undergoing neurosurgery
- description
- Samples of tumor tissue, blood, CSF, saliva, skull, and dura will be taken during neurosurgery from tumor patients meeting the inclusion criteria.
- label
- Parents of tumor patients
- description
- Saliva samples will be taken from parents of tumor patients meeting the inclusion criteria.
- label
- Cohort 2: Non-Tumor patients undergoing neurosurgery
- description
- Blood and CSF samples will be taken from non-tumor patients meeting the inclusion criteria.
- label
- Cohort 3: Autopsy tumor tissue donation
- description
- Post-mortem biospecimens such as whole brain, spinal cord, biofluids (e.g., cerebrospinal fluid and blood) and skin biopsy will be collected through autopsy donation from brain tumor patients meeting the inclusion criteria.
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria for Tumor patients undergoing neurosurgery (cohort 1) 1. Subject has presented with a suspected/confirmed neoplastic CNS lesion and is undergoing a neurosurgical procedure in which CNS tissue and/or tumors associated with this tissue will be removed. 2. There must be tissue available in excess of that required by neuropathology for diagnostic purposes. 3. Subject of all ages included. 4. Subjects who are pregnant can be included. 5. Subjects who are neonates (0-4 weeks) can be included. Inclusion Criteria for Non-tumor patients undergoing neurosurgery (cohort 2) 1. Subject is between 4 weeks and 21 years of age and is undergoing a neurosurgical procedure at WCMC. 2. Subject does not have a CNS tumor diagnosis. 3. Subject should not be pregnant at the time of enrollment. Inclusion Criteria for Autopsy tumor tissue donation (cohort 3) 1. Subject of all ages included 2. Subject has been diagnosed with a neoplastic CNS lesion at the time of passing. 3. Subjects who are pregnant can be included. 4. Subjects who are neonates (0-4 weeks) can be included. Inclusion Criteria for parent of tumor patients 1. Subject is the biological parent of a patient undergoing/ who underwent a neurosurgical procedure in which CNS tissue and/or tumors associated with this tissue will be/ was removed. 2. Subject is the biological parent of patient enrolled in cohort 1. 3. Subject is not pregnant at the time of enrollment.
References
Publications (1)
- BACKGROUNDRajappa P, Cobb WS, Vartanian E, Huang Y, Daly L, Hoffman C, Zhang J, Shen B, Yanowitch R, Garg K, Cisse B, Haddock S, Huse J, Pisapia DJ, Chan TA, Lyden DC, Bromberg JF, Greenfield JP. Malignant Astrocytic Tumor Progression Potentiated by JAK-mediated Recruitment of Myeloid Cells. Clin Cancer Res. 2017 Jun 15;23(12):3109-3119. doi: 10.1158/1078-0432.CCR-16-1508. Epub 2016 Dec 30. PMID 28039266