Clinical trial · Observational
Endocrine Disrupting Chemical Exposure and Testicular Cancer
Prenatal Exposure to Endocrine Disrupting Chemicals and Risk of Testicular Cancer in Offspring
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
DISRUPT is a Danish nested case-control study that is currently being conducted to explore the impact of prenatal exposure to endocrine disrupting chemicals on testicular cancer risk (including histological sub-groups) with emphasis on the analysis of exposure mixtures. Pregnant mothers provided serum and amniotic fluid at recruitment up to 50 years ago. By registry linkage within highly reliable national population and disease registries cancer cases and matched controls will be identified. Levels of EDCs including DDT, DDE and other organochlorine pesticides, PCBs, PBDEs, PFAS, phthalates and triclosan will be quantified in cases whose sons develop testicular cancer during 40 year follow up and compared to controls.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Testicular Cancer | Malignant Testicular Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Observational | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Live-born sons (with and without testicular cancer diagnosis) from a Danish pregnancy Cohort
- description
- Pregnancy cohort: Biological samples from 128,702 of pregnant women were stored for research purposes in the Danish National Biobank, in the period from 1976-2004. Present study: live-born sons (with/without testicular cancer ascertained via data linkage in the Danish Cancer Registry)
- interventionNames
- Other: Observational
Primary outcomes (1)
- measure
- Risk of testicular Cancer (ICD-10 code)
- timeFrame
- Testicular cancer is ascertained in live-born sons within the cohort, during the follow-up period (up to 50 years)
- description
- Ascertained in adult men - Registry based on ICD-10 codes for testicular cancer (C62\*)
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 15 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Male * Available stored maternal serum and/or maternal amniotic fluid Exclusion Criteria: * other cancer
References
Publications (0)
Data not yet available