R2-CHOP in Untreated DEL-DLBCL：An Open-lable，Multicenter，Phase II Study

Inclusion Criteria:

* Patients with MYC and BCL2 co-expression Diffuse Large B-Cell Lymphoma diagnosed by histopathologyImmunohistochemistry confirmed that the positive expression rate of BCL-2≥50% and c-Myc≥ 40%.
* Male or female patients: 18-80 years old.
* ECOG physical condition score: 0-2 points for patients.
* IPI score≥3.
* Patients have not received any anti-tumor therapy such as radiotherapy, chemotherapy, targeted therapy or stem cell transplantation.
* In those patients with at least one evaluable or measurable lesion meeting Lugano 2014 criteria, the evaluable lesion was: 18F fluorodeoxyglucose / positron emission tomography (18FDG / PET) examination showed that the uptake of lymph nodes or extranodal areas was increased (higher than that of liver) and pet and / or computed The features of tomography (CT) were in accordance with lymphoma. The measurable lesions were nodal lesions with a length of \> 15 mm or extranodal lesions with a length of \> 10 mm, accompanied by an increase in 18FDG uptake. There was no measurable lesion and the uptake of 18FDG was increased.
* Patients with good function of main organs, i.e. one week before admission, met the following requirements: WBC \>= 3.5×10\^9 / L, NEU≥1.5×10\^9/L, Hb \>= 80g / L, PLT \>= 100 ×10\^9 / L; heart and liver functions were normal (total bilirubin \<= 1.5 times of normal value, ALT and AST \<= 2.5 times of normal value), renal functions were normal (serum creatinine \<= 1.5 times of normal value), and coagulation function was not abnormal.
* LVEF≥50%, measured by echocardiography.
* No other tumor-specific concomitant therapy has been administered (including steroids).
* Pregnant women of childbearing age must have a pregnancy test (serum or urine) within 14 days before enrollment and the result is negative, and they are willing to use reliable methods of contraception during the test.
* Patients have no other serious diseases in conflict with this clinical trial protocols.
* The subjects who volunteer to join the study and sign the informed consent form, have good compliance and cooperate with the follow-up.

Exclusion Criteria:

* Other types of DLBCL: Diffuse large B-cell lymphoma associated with chronic inflammation, lymphomatoid granulomatosis, Primary mediastinal (thymic) large B-cell lymphoma, ALK-positive large B-cell lymphoma, Primary effusion lymphoma, Burkitt lymphoma, High-grade B-cell lymphoma(including High-grade B-cell lymphoma, NOS, High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements), B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classic Hodgkin lymphoma, Primary diffuse large B-cell lymphoma of the CNS, EBV-positive diffuse large B-cell lymphoma.
* Transformed DLBCL (transformed DLBCL from follicular lymphoma, chronic lymphocytic leukemia/small B lymphocytic lymphoma), Diffuse large B-cell lymphoma with secondary involvement of the central nervous system (SCNS-DLBCL).
* Other malignancies within the past 5 years except for carcinoma of the cervix or basal or squamous cell carcinomas of the skin.
* Major surgical procedures (excluding diagnostic surgical procedures) performed in the past 2 months.
* Prior treatment for NHL, concomitant chemotherapy, radiotherapy immunotherapy, monoclonal antibody therapy, surgical treatment (except for diagnostic surgery and biopsy).
* Prior treatment with cytotoxic drugs or anti-CD20 monoclonal antibody for other conditions (e.g. Rheumatoid arthritis)
* Prior treatment with thalidomide, lenalidomide, or other drugs.
* Prior treatment with any monoclonal antibody within the preceding 3 months. Prior treatment with live (attenuated) virus vaccine within the preceding 1 month.
* Patients taking hematopoietic cytokines within 2 weeks before enrollment.
* Patients with suspected active or latent TB infections.
* Patients with known active bacterial, viral, fungal, mycobacterium, parasitic or other infections (excluding fungal nail infection) or any serious systemic infections requiring intravenous antibiotic treatment or hospitalization (excluding neoplastic fever) in the 4 weeks prior to enrollment.
* Other serious conditions that may limit patients participation in the trial, such as Uncontrolled diabetes, Severe cardiac insufficiency (NYHA grade II or above), Acute coronary syndrome in the last 6 months, Coronary revascularization includes stent implantation, coronary artery bypass surgery, and other cardiac and vascular related procedures in the last 6 months, severe arrhythmia (including frequent ventricular premature beats, ventricular tachycardia , fast atrial fibrillation/ atrial flutter, severe bradycardia), Uncontrolled high blood pressure(\>150/100mmHg), gastric ulcer(gastric ulcers were at risk of perforation), Active autoimmune disease, Severe hypertension, Severe respiratory disease(obstructive pulmonary disease or history of bronchospasm).
* Any contraindication of the CHOP drugs, including previously received anthracycline antibiotics; Patients with diabetes cannot tolerate prednisone therapy.
* Patients had a history of alcohol abuse or drug abuse.
* Allergic physique or known sensitivity or allergy to the active ingredient, excipient, murine products, heterologous proteins of any drug used in this treatment(including CHOP).
* Patients with serious mental illness.
* Patients who are unable to comply during the trial and/or follow-up phase.
* The researchers considered the patients unsuitable for the study.