Clinical trial · Observational
Predictive OCTA Biomarkers After Endoscopic Endonasal Pituitary Surgery
Optical Cohrence Tomography Angiography as a New Predictive Biomarker in Anatomical and Functional Recovery After Endoscopic Endonasal Pituitary Surgery: a Prospective Study
NCT04840771CI-TRIAL-00051651completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study evaluates the structural parameters, by spectral domain optical coherence tomography (OCT), retinal vessel density, using OCT angiography, and visual acuity in patients that received endoscopic endonasal approach for the removal of an intra-suprasellar pituitary adenoma compressing the optic nerve.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pituitary Adenoma | Pituitary Neuroendocrine Tumor | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Endoscopic Endonasal Pituitary Surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Comparison between retinal structures before and 48 hours and 1 year after Endoscopic Endonasal Pituitary Surgery
- timeFrame
- 48 hours and 1 year follow up
- description
- 8 patients with pituitary adenoma compressing optic chiasm. Changes in thickness of ganglion cell complex (microns) and in thickness of retinal nerve fiber layer (microns) before and 48 hours and 1 year after Endoscopic Endonasal Pituitary Surgery
- measure
- Comparison between retinal microvasculature before and 48 hours and 1 year after Endoscopic Endonasal Pituitary Surgery
- timeFrame
- 48 hours and 1 year follow up
- description
- 8 patients with pituitary adenoma compressing optic chiasm. Changes in retinal vessel density (percent) in macular and papillary regions before and 48 hours and 1 year after Endoscopic Endonasal Pituitary Surgery
Secondary outcomes (2)
- measure
- Correlation between retinal structures and visual acuity after Endoscopic Endonasal Pituitary Surgery
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * age older than 40 years * diagnosis of pituitary adenoma * treatment-naïve with Endoscopic Endonasal Pituitary Surgery * absence of other neurological diseases * absence of vitreoretinal and vascular retinal diseases Exclusion Criteria: * age younger than 40 years * No diagnosis of pituitary adenoma * previous treatments with Endoscopic Endonasal Pituitary Surgery * presence of neurological diseases * presence of vitreoretinal and vascular retinal diseases
References
Publications (0)
Data not yet available
No reference posted for this study.