Clinical trial · Observational
Postoperative Cognitive Dysfunction in Elderly Urologic Oncology Patients (POCD)
Evaluation of the Relationship Between Postoperative Cognitive Dysfunction and Brain Injury Biomarkers In Geriatric Urologic Oncology Patients
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Postoperative cognitive changes are more common in elderly patients, which can result in poor quality of life, loss of workforce, disability, early retirement, physical-social dependence, increased health care cost and premature mortality. Postoperative cognitive complications are also quite common in extensive oncological surgeries. In this study, our aim is to evaluate the relationship between the development of postoperative cognitive dysfunction (POCD) in geriatric urologic oncology patients with brain injury and inflammatory markers \[S100 β, neuron specific enolase (NSE), interleukin 6 (IL-6) and high mobility group box-1 (HMGB-1 protein)\].
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Frailty | — | UNRESOLVED | — |
| Postoperative Cognitive Dysfunction | — | UNRESOLVED | — |
| Postoperative Delirium | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Addenbrooke Cognitive Examination III (ACE-III) | Diagnostic Test | — | UNRESOLVED |
| Blood sample | Diagnostic Test | — | UNRESOLVED |
| Confusion Assessment Method | Diagnostic Test | — | UNRESOLVED |
| Near Infrared Spectroscopy (NIRS) | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Urologic oncology surgery in elderly
- description
- Elective urologic oncology surgeries such as radical nephrectomy, radical cystectomy, radical prostatectomy in older than 65 years
- interventionNames
- Device: Near Infrared Spectroscopy (NIRS)
- Diagnostic Test: Blood sample
- Diagnostic Test: Addenbrooke Cognitive Examination III (ACE-III)
- Diagnostic Test: Confusion Assessment Method
Primary outcomes (7)
- measure
- Addenbrooke cognitive examination at the day before surgery.
- timeFrame
- The day before surgery.
- description
- Test score is between 0-100. 100 is the best point and 0 is the worst point in the test. The test has five cognitive domains including attention, memory, language, visuospatial function, and verbal fluency. Patients who score less than 88 in preoperative tests will be diagnosed with mild cognitive impairment.
- measure
- Addenbrooke cognitive examination at seventh day after surgery.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Patients over the age of 65 who are planned to undergo major urooncological surgery. Exclusion Criteria: * Patients who refuse to participate in the study. * Patients with severe hearing-vision problems. * Patients with serious neurological-psychiatric disorders. * Patients with language barrier. * Patients with missing in any interventions. * Patients with blood samples that are not suitable for the ELISA.
References
Publications (6)
- BACKGROUNDYanagisawa R, Tanaka M, Yashima F, Arai T, Kohno T, Shimizu H, Fukuda K, Naganuma T, Mizutani K, Araki M, Tada N, Yamanaka F, Shirai S, Tabata M, Ueno H, Takagi K, Higashimori A, Watanabe Y, Yamamoto M, Hayashida K. Frequency and Consequences of Cognitive Impairmentin Patients Underwent Transcatheter Aortic Valve Implantation. Am J Cardiol. 2018 Sep 1;122(5):844-850. doi: 10.1016/j.amjcard.2018.05.026. Epub 2018 Jun 2. PMID 30072128
- BACKGROUNDRundshagen I. Postoperative cognitive dysfunction. Dtsch Arztebl Int. 2014 Feb 21;111(8):119-25. doi: 10.3238/arztebl.2014.0119. PMID 24622758
- BACKGROUNDPlas M, Rotteveel E, Izaks GJ, Spikman JM, van der Wal-Huisman H, van Etten B, Absalom AR, Mourits MJE, de Bock GH, van Leeuwen BL. Cognitive decline after major oncological surgery in the elderly. Eur J Cancer. 2017 Nov;86:394-402. doi: 10.1016/j.ejca.2017.09.024. Epub 2017 Nov 5. PMID 29100194
- BACKGROUNDKapoor I, Prabhakar H, Mahajan C. Postoperative Cognitive Dysfunction. Indian J Crit Care Med. 2019 Jun;23(Suppl 2):S162-S164. doi: 10.5005/jp-journals-10071-23196. PMID 31485127
- BACKGROUNDFournier A, Krause R, Winterer G, Schneider R. Biomarkers of postoperative delirium and cognitive dysfunction. Front Aging Neurosci. 2015 Jun 9;7:112. doi: 10.3389/fnagi.2015.00112. eCollection 2015. PMID 26106326
- BACKGROUNDLi RL, Zhang ZZ, Peng M, Wu Y, Zhang JJ, Wang CY, Wang YL. Postoperative impairment of cognitive function in old mice: a possible role for neuroinflammation mediated by HMGB1, S100B, and RAGE. J Surg Res. 2013 Dec;185(2):815-24. doi: 10.1016/j.jss.2013.06.043. Epub 2013 Jul 17. PMID 23899512