Clinical trial · Interventional
Promoting Equity for Cancer Screening and Follow-up
Promoting Equity Through Multicomponent Strategies for Cancer Screening and Follow-up (PREMiS)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Insufficient study resources and change in practice.
Summary
Brief summary (as posted)
This is a randomized trial to assess the efficacy of reminder mechanisms on colorectal cancer (CRC) screening uptake among a cohort of patients who were previously mailed a multitarget stool DNA (mt-sDNA) test and did not complete the screening. Patients will be identified as being due for CRC screening and will be mailed a mt-sDNA kit to their home. Patients who do not complete screening with mt-sDNA within 30 days will be identified and randomized into one of three study arms to receive reminders to complete the mt-sDNA screening. The primary outcome is the rate of completion of screening for colorectal cancer with mt-sDNA test.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal (Colon or Rectal) Cancer | Childhood Colorectal Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| EHR Portal message | Other | — | UNRESOLVED |
| IVR Reminder | Other | — | UNRESOLVED |
| Phone call from research team | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- IVR Reminder
- description
- Participants will receive an interactive voice reminder
- interventionNames
- Other: IVR Reminder
- type
- ACTIVE_COMPARATOR
- label
- Personalized Phone Call Reminder
- description
- Participants will receive a personalized phone call
- interventionNames
- Other: Phone call from research team
- type
- ACTIVE_COMPARATOR
- label
- Portal Message Only
- description
- Participants will receive a online patient portal message reminder
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Adults, between 50 to 75 years old. * Due for colorectal cancer screening based on not having a record of a colonoscopy within 10 years, sigmoidoscopy, or CT colonography within 5 years, mt-sDNA within 3 years, or FIT within 1 year. * Asymptomatic for colorectal cancer such as rectal bleeding or reported abdominal mass. Exclusion Criteria: * For the intervention study, patients will be restricted to those aged 50 to 75 years and are due for colorectal cancer screening. * We will exclude any patient who has: * Had prior colonoscopy within 10 years, sigmoidoscopy within 5 years, mt-sDNA within 3 years, CT colonography within 5 years, and FOBT/FIT within twelve months of inclusion into the study; * A diagnosis of CRC or other GI cancer; * History of confirmed Inflammatory Bowel Disease (Crohn's disease, ulcerative colitis) or other colitis; * Had a colectomy, partial or total; * A diagnosis of Lynch Syndrome; * A diagnosis of Familial Adenomatous Polyposis (FAP); * Iron deficiency anemia; * Lower GI bleeding; * A metastatic (Stage IV) blood or solid tumor cancer; * End stage renal disease; * A first degree relative with CRC prior to age 50 or 2+ first degree relatives diagnosed at any age.
References
Publications (0)
Data not yet available