Clinical trial · Interventional

Quadratus Lumborum Block Versus Thoracic Paravertebral Block

Ultrasound Guided Quadratus Lumborum Block Versus Thoracic Paravertebral Block in Gynacological Cancer Surgery

NCT04827043CI-TRIAL-00050991unknownN/AClinicalTrials.gov clinicaltrialsPublishedExplore in graph →

Summary

Brief summary (as posted)

This study is to assess and compare the analgesic efficacy and safety of quadratus lumbotum block and paravertebral block in gynacological cancer patients.

Conditions

Conditions (1)

Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.

Condition (as posted)	Mapped entity	Match	Confidence
Postoperative Analgesia	—	UNRESOLVED	—

Interventions

Interventions (2)

Intervention	Type	Mapped drug	Match
Ultrasound guided quadratus lumborum block	Combination Product	—	UNRESOLVED
Ultrasound guided thoracic paravertebral block	Combination Product	—	UNRESOLVED

Design

Arms and outcomes

Arms (2)

type
EXPERIMENTAL
label
Quadratus lumborum block
description
QLB group: will receive 0.3ml/Kg bupivacaine 0.25% ( keeping in mind not to exceed the maximum recommended toxic dose of plain bupivacaine which is 2.5 mg/Kg \& 3mg/Kg with epinephrine), single injection sonar guided.
interventionNames
1. Combination Product: Ultrasound guided quadratus lumborum block
type
EXPERIMENTAL
label
Thoracic paravertebral block
description
PVB group: will receive 0.25ml/Kg/side of 0.375% bupivacaine with epinephrine 5ug/ml, yielding the same dose of bupivacaine of 1.875mg/ml at the level of T10 as a single injection sonar guided.
interventionNames
1. Combination Product: Ultrasound guided thoracic paravertebral block

Primary outcomes (1)

measure

Eligibility

Eligibility (as posted)

Sex: Female
Minimum age: 20 Years
Maximum age: 70 Years

Show eligibility criteria text

1\. Inclusion criteria

1. ASA I-III.
2. Age ≥ 20 \& ≤ 70
3. Body mass index (BMI): Less than forty and more than twenty.
4. Patients undergoing major gynacological cancer surgeries.

2\. Exclusion criteria

1. Patient refusal.
2. History of sensitivity to local anesthetic (amide group).
3. History of psychological disorders.
4. Coagulopathies: hereditary (e.g. hemophilia, fibrinogen abnormalities\& deficiency of factor II) - acquired (e.g. liver disease, vitamin K deficiency \& therapeutic anticoagulants drugs).
5. Localized infection.
6. Morbid obese BMI\>40.
7. Incooperative patients.
8. Patients on chronic pain therapy.

References

Publications (2)

BACKGROUNDUeshima H, Otake H, Lin JA. Ultrasound-Guided Quadratus Lumborum Block: An Updated Review of Anatomy and Techniques. Biomed Res Int. 2017;2017:2752876. doi: 10.1155/2017/2752876. Epub 2017 Jan 3. PMID 28154824
BACKGROUNDBlanco R, Ansari T, Riad W, Shetty N. Quadratus Lumborum Block Versus Transversus Abdominis Plane Block for Postoperative Pain After Cesarean Delivery: A Randomized Controlled Trial. Reg Anesth Pain Med. 2016 Nov/Dec;41(6):757-762. doi: 10.1097/AAP.0000000000000495. PMID 27755488