Clinical trial · Interventional
Liver Transplantation for Unresectable GIST Liver Metastases
Liver Transplantation in Patients With Unresectable GastroIntestinal Stromal Tumors (GIST) Liver Metastases
NCT04825470CI-TRIAL-00057066TRANSGISTunknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Liver Transplantation for Unresectable GIST Liver Metastases
Conditions
Conditions (28)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastrointestinal Stromal Tumor by AJCC V8 Stage | Gastrointestinal Stromal Tumor by AJCC v8 Stage | ONTOLOGY_EXACT | 0.98 |
| Gastrointestinal Stromal Tumor (GIST) of the Gastrointestinal Tract | Gastrointestinal Stromal Tumor of the Gastrointestinal Tract | ALIAS | 0.90 |
| Gastrointestinal Stromal Tumor, Malignant | Malignant Gastrointestinal Stromal Tumor | ALIAS | 0.90 |
| Gastrointestinal Stromal Tumor of Duodenum | — | UNRESOLVED | — |
| Gastrointestinal Stromal Tumor of Esophagus (Disorder) | Esophageal Gastrointestinal Stromal Tumor | ALIAS | 0.85 |
| Gastrointestinal Stromal Tumor of Large Intestine (Disorder) | Colorectal Gastrointestinal Stromal Tumor | ALIAS | 0.85 |
| Gastrointestinal Stromal Tumor of Other Sites | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Liver Transplantation | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Liver Transplantation
- interventionNames
- Procedure: Liver Transplantation
Primary outcomes (2)
- measure
- Overall Survival
- timeFrame
- Through study completion, an average of 2 years
- description
- Survival
- measure
- Graft Survival
- timeFrame
- Through study completion, an average of 2 years
- description
- Liver graft Survival
Secondary outcomes (2)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * GIST diagnosis (c-Kit, CD34, DOG-1) * Imatinib-sensitive mutation * Non-resectable liver metastases * Abscence of extrahepatic disease * Period greater than two years between primary tumor and metastases diagnosis
References
Publications (1)
- BACKGROUNDFernandez JA, Alconchel F, Gomez B, Martinez J, Ramirez P. Unresectable GIST liver metastases and liver transplantation: A review and theoretical basis for a new indication. Int J Surg. 2021 Oct;94:106126. doi: 10.1016/j.ijsu.2021.106126. Epub 2021 Sep 27. PMID 34592432