Clinical trial · Interventional
DWI in the Diagnosis of Histological Types of Nephroblastoma in Children
Diffusion-weighted Images as an Additional Method for Diagnosing Histological Types of Nephroblastoma in Children
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Initially, or after preoperative chemotherapy, patients with a kidney tumor are examined on 3T MR scanner or 1.5T MR scanner. A standard MRI study of the abdomen with contrast enhancement is performed. DWI (diffusion weighted) images are included in the standard investigation package and consist of diffusion maps. Then, using Philips workstation (ISP 9.0, Philips, Netherlands), DWI mapping and ADC values collection (mm2/s) are performed. The placement of region of interest (ROI) is selected in the kidney mass in a solid and cystic area with a size up to 100 mm2. After the preoperative abdomen MRI, a surgical treatment is performed. Histological material is directed to the pathologist, who carried out the histological staging by the malignancy degree (low, intermediate, high). The data is entered into the database and the relationship between ADC values and histological degrees of malignancy of nephroblastoma is investigated
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Nephroblastoma (Wilms Tumour) | Wilms Tumor | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| MRI DWI sequence (ADC values) | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- To evaluate the differences in ADC values according to the malignancy degree of nephroblastoma in children
- timeFrame
- Point 1. 15 ± 3 days Before the start of therapy - the starting point.
- measure
- To evaluate the differences in ADC values according to the malignancy degree of nephroblastoma in children
- timeFrame
- Point 2. after pre-operative chemotherapy up to 1 week
Secondary outcomes (8)
- measure
- To evaluate the reproducibility and compatibility of the ADC values measurement;
- timeFrame
- Point 1. 15 ± 3 days Before the start of therapy - the starting point.
- measure
- To evaluate the reproducibility and compatibility of the ADC values measurement;
- timeFrame
- Point 2. after pre-operative chemotherapy up to 1 week
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 6 Days
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age under 18 y.o.; 2. Renal mass with confirmed histology. Exclusion Criteria: 1. Absolute contraindications to magnetic resonance imaging (pacemaker, ferromagnetic implants, etc.); 2. Refusal to sign the informed consent.
References
Publications (0)
Data not yet available