Clinical trial · Interventional
Intraperitoneal Tramadol Versus Dexmedetomedine for Analgesia After Abdominal Laparoscopic Cancer Surgeries
Comparative Study Between Intraperitoneal Administration of Either Bupivacaine and Tramadol Versus Bupivacaine and Dexmedetomedine for Analgesia After Abdominal Laparoscopic Cancer Surgeries. A Prospective Randomized Pilot Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Multiple modalities for postoperative analgesia after laparoscopic procedures has been used, of them intraperitoneal route (IP) was used to decrease the analgesic requirements. Both early and late bupivacaine and tramadol versus bupivacaine and dexmedetomedine will be tried to choose which is having a better analgesic profile.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Analgesia | — | UNRESOLVED | — |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dexmedetomidine 1 | Drug | — | UNRESOLVED |
| dexmedetomidine 2 | Drug | — | UNRESOLVED |
| Tramal 1 | Drug | — | UNRESOLVED |
| Tramal 2 | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- ACTIVE_COMPARATOR
- label
- Early tramal/bupivacaine
- description
- patients received 50 ml of isotonic aqueous solution (PH 7.45) of tramadol 150mg mixed with bupivacaine 0.25% immediately before creation of a pneumoperitoneum and placement of the first two trocars before starting the surgery.
- interventionNames
- Drug: Tramal 2
- Drug: Dexmedetomidine 1
- Drug: dexmedetomidine 2
- type
- ACTIVE_COMPARATOR
- label
- Late tramal/bupivacaine
- description
- patients received 50ml of isotonic aqueous solution (PH 7.45) of tramadol 150mg mixed with bupivacaine 0.25% after completion of surgery and before trocars removal.
- interventionNames
- Drug: Tramal 1
- Drug: Dexmedetomidine 1
- Drug: dexmedetomidine 2
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * ASA II or III. * Age 18 to 65 years. * Elective surgeries Exclusion Criteria: * Patients with severe hepatic (more than child c), renal (known CKD)and cardiac (known IHD) troubles. * Patients with extensive intraperitoneal adhesions. * Patients with a history of drug or analgesic abuse. * Known drug allergy or indigestion. * Intraoperative lavage of more than 500ml.
References
Publications (1)
- DERIVEDShaker EH, Soliman MS, Hanafy A, Elsabeeny WY. Comparative Study Between Early versus Late Intraperitoneal Administration of Either Bupivacaine/Tramadol or Bupivacaine/Dexmedetomidine for Perioperative Analgesia in Abdominal Laparoscopic Cancer Surgeries: A Prospective Randomized Study. J Pain Res. 2022 Oct 18;15:3233-3243. doi: 10.2147/JPR.S376681. eCollection 2022. PMID 36281310