Clinical trial · Interventional
Surgical Resection of Latent Brain Tumors Prior to Recurrence
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): internal procedural reasons
Summary
Brief summary (as posted)
This clinical trial evaluates the side effects and possible benefits of operating on brain tumors prior to the tumor coming back (recurrence). Understanding when surgery is most useful to patients with brain tumors is important. Some patients may undergo chemotherapy or radiation but still have visible tumor remaining after treatment. The purpose of this research is to compare outcomes of those who have surgery after chemotherapy or radiation, but prior to tumor recurrence, to those who have surgery at a different time, or no surgery at all.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Brain Neoplasm | Brain Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Brain Surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Treatment (surgery)
- description
- Patients undergo surgery as indicated clinically when applicable.
- interventionNames
- Procedure: Brain Surgery
Primary outcomes (2)
- measure
- Feasibility of surgical resection by short and long term outcomes
- timeFrame
- Up to 5 years
- description
- Feasibility will be evaluated by meeting enrollment criteria.
- measure
- Incidence of adverse events
- timeFrame
- Up to 5 years
- description
- Safety will be evaluated by recording adverse events utilizing proper reporting measures.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age \>= 18 years * Histological or cytological confirmation of brain tumor and/or suspected brain tumor based on clinical and radiologic findings * Prior chemotherapy and/or radiation treatment directed to the known/suspected tumor * Radiographic evidence of residual or previously unresected tumor * Willingness to undergo surgery and sign informed consent * Patients not currently eligible for an alternate competing interventional clinical trial * Enrollment in the Mayo Clinic Cancer Center Neuro-Oncology Program Registry for the study of Nervous System Tumors (IRB#12-003458) Exclusion Criteria: * Age \< 18 years * Found to be a member of a vulnerable population (e.g. pregnant, lacking capacity to consent) during the course of pre-enrollment or pre-surgical assessment * Prior gross total resection of brain tumor leading to absence of visible latent disease (exemption available for post-operative enrollment) * Any contraindication to surgery, including anyone who in the opinion of the surgeon is at unreasonably elevated risk of wound complications * Patients who have not yet undergone surgery or radiation, but who would be appropriate candidates for an alternate interventional clinical trial (e.g. post-operative fractionated vs single fraction radiation to the surgical cavity for surgical brain metastases)
References
Publications (0)
Data not yet available