Clinical trial · Observational
Does Notch Regulate Glioma Proliferation ?
Study of the Activity and Role of Notch1 Signalling in Glioma
NCT04809597CI-TRIAL-00050802GLIONOTCHcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The investigators showed in 2015 (Guichet et al) that the Notch1 pathway has an anti-proliferative role on glial brain tumors. In this project, the investigators investigated which genes downstream of Notch1 pathway activation produce the anti-proliferative effect. The investigators hypothesized that the SNAI2 and TAL1 genes act downstream of Notch1
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Glioma | Glioma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (2)
- measure
- Effect of Notch1 activation on Tal1
- timeFrame
- 1 day
- description
- highthroughput gene analysis (DNA arrays) with cells transduced with activated form of Notch1
- measure
- Snai2 gene and protein expression
- timeFrame
- 1 day
- description
- western blot for Tal1 and Snai2 in protein extracted from low grade and high gliomas
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion criteria: * Patient ≥18 years old * Patient affected with brain glioma classified according to WHO 2016 classification Exclusion Criteria: * Patient who reject the study protocol * Radiotheray or chemotherapy treatment
References
Publications (0)
Data not yet available
No reference posted for this study.